NF-κB: master regulator of cellular responses in health and disease by Alexander Hoffmann & Genhong Cheng & David Baltimore instant download

NF-κB: master regulator of cellular responses in health and disease by Alexander Hoffmann & Genhong Cheng & David Baltimore instant download

Immunity & InflammationAbstractThe NF-κB transcription control proteins play widespread roles in cellular behavior, regulating immune responses, infammation, cell survival, proliferation, and development. Here, we attempt to comprehensively review these diverse functions and underlying mechanisms, leading readers to relevant references of both historic and topical importance. Because of the huge number of NF-κB control mechanisms and functions, and the vast literature that describes these, being comprehensive is a daunting task but we hope that readers will fnd clues to lead them to whatever understanding they may seek. Additionally, we discuss recent therapeutic advancements targeting NF-κB signaling in various diseases.Keywords NF-κB, Signal transduction pathway, Transcription regulation, Immune response, Infammation, Infammatory diseases,