Distinct subpopulations of parvalbumin neurons participating in divergent prefrontal functions by Yehong Hu & Xinyang Zhang & Tsz Hei Fong & Tianyu Wang & Jin Zhang & Yujie Zhang & Qiang Zhou instant download

Distinct subpopulations of parvalbumin neurons participating in divergent prefrontal functions by Yehong Hu & Xinyang Zhang & Tsz Hei Fong & Tianyu Wang & Jin Zhang & Yujie Zhang & Qiang Zhou instant download

Prefrontal parvalbumin (PV) neurons play crucial roles in various distinct functions, while malfunction of PV-neurons also has criticalcontributions to various brain diseases, including both psychiatric and neurodegenerative disorders. However, whether theprefrontal cortex (PFC) PV-neurons participating in these functions and malfunctions are distinct subpopulations is not wellunderstood. This question is important for a better understanding of both the basic properties/function of PV-neurons andinhibitory neurons in general, and for potential comorbid occurrence of dysfunctions in disease settings. Here, we analyzeddorsomedial prefrontal cortex (dmPFC) PV-neurons participating in working memory, modulation of conditioned fear memory, andanxiety, regarding their relative localization, electrophysiological properties, and synaptic inputs. In addition, by using activitydependent tagging method, we examined whether manipulating the dmPFC PV-neurons participating in one function may affect1234567890();,:another function as a way to test for potential functional interactions between them. We found that: (1) one single group of dmPFCPV-neurons participating in the two forms of modulation of conditioned fear memory, based on their high overlap in localizationand mutual functional interactions with each other. (2) dmPFC PV-neurons participating in fear memory modulation and anxiety aretwo different subpopulations, with unique electrophysiological properties. (3) dmPFC PV-neurons participating in working memoryand fear memory modulation are two different subpopulations, with different synaptic and neuronal properties. These findingsprovide important insights into the organization of PV-neurons in the PFC and highlight the distinct and non-interacting nature ofdifferent PV-subpopulations in the PFC functional diversity.Neuropsychopharmacology;