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(Ebook) CNS Cancer Models Markers Prognostic Factors Targets and Therapeutic Approaches 1st Edition by Marcela Assanah, Kim A Lopez, Jeffrey N Bruce, Peter Canoll, Erwin G Meir ISBN 9781603275521 1603275525

  • SKU: EBN-11849634
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Authors:Marcela Assanah, Kim A. Lopez, Jeffrey N. Bruce, Peter Canoll (auth.), Erwin G. Meir (eds.)
Pages:1284 pages.
Year:2009
Editon:1
Publisher:Humana Press
Language:english
File Size:30.18 MB
Format:pdf
ISBNS:9781603275521, 9781603275538, 1603275525, 1603275533
Categories: Ebooks

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(Ebook) CNS Cancer Models Markers Prognostic Factors Targets and Therapeutic Approaches 1st Edition by Marcela Assanah, Kim A Lopez, Jeffrey N Bruce, Peter Canoll, Erwin G Meir ISBN 9781603275521 1603275525

(Ebook) CNS Cancer Models Markers Prognostic Factors Targets and Therapeutic Approaches 1st Edition by Marcela Assanah, Kim A Lopez, Jeffrey N Bruce, Peter Canoll, Erwin G Meir - Ebook PDF Instant Download/Delivery: 9781603275521 ,1603275525
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ISBN 10: 1603275525
ISBN 13: 9781603275521
Author: Marcela Assanah, Kim A Lopez, Jeffrey N Bruce, Peter Canoll, Erwin G Meir

CNS Cancer: Models, Markers, Prognostic Factors and Therapeutic Approaches
__Erwin G. Van Meir__
Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies.This makes it an especially opportune time to assemble some of the best investigators in the field to review the "state of the art" in the various arenas that comprise the assault on CNS tumors. While the lethality of these tumors has remained dismal over the past decades, there is finally real reason for optimism as our knowledge base grows exponentially larger.
The major areas of this endeavor are displayed in CNS Cancer: Models, Markers, Prognostic Factors and Therapeutic Approaches. Each of the chapters in the book represents illustrative examples of the road from discovery through translation to clinical importance, although many begin the journey at different parts of this continuum. This includes several chapters on incredibly clever mouse models for deciphering the genetic wiring underlying the development of CNS tumors and how that wiring might be targeted for therapeutic benefit. A great deal of attention has been paid in the book to the development of genetic prognostic factors and biomarkers that could be used for assessing individual responses to therapies and so could lead to truly personalized medicine. Other possible prognostic factors/biomarkers that arise from an understanding of CNS tumor pathophysiology are discussed in some detail and include tumor vascularization and hypoxia. Several of the new and rapidly developing methodologies that allow these rapid advances are detailed for the reader as well and include RNA expression profiling, proteomic analyses of both tumors and biological fluids as well as profiling small non-coding RNAs and DNA modification. Finally, several chapters explore aspects of therapeutic targeting employing small molecules and combinations thereof, various sorts of cells, viruses and immune modulation. In sum, these treatises represent the cutting edge of research that is driven to be of benefit to patients with these dreaded diseases.
Erwin G. Van Meir is Professor of Neurosurgery and Hematology & Medical Oncology in the School of Medicine at Emory University. A native of Belgium, he obtained Bachelor’s degrees in Biology and Education at the University of Fribourg, Switzerland. Dr Van Meir is an active member of the International Neuro-Oncology community and served on the Board of Directors of the Society for Neuro-Oncology from 2004-2008. Dr. Van Meir currently serves on the Editorial Board of Neuro-Oncology, Frontiers in Bioscience, and International Journal of Oncology and is a former Associate Editor of the International Journal of Cancer. He has served as a reviewer for over 30 international scientific journals and for grant proposals from public and private agencies.

(Ebook) CNS Cancer Models Markers Prognostic Factors Targets and Therapeutic Approaches 1st Edition Table of contents:

Part I. Animal Models for central nervous tumors
Modeling gliomas using PDGF-expressing retroviruses
Modeling brain tumors using avian retroviral gene transfer
Using neurofibromatosis type 1 mouse models to understand human pediatric low-grade gliomas
Transgenic mouse models of CNS tumors: using genetically engineered murine models to study the role of p21 Ras in glioblastoma multiforme
PTEN-deficient mouse models for high-grade astrocytomas
The Nfl-/+; Trp53-/+cis mouse model of anaplastic astrocytoma and secondary glioblastoma : dissecting genetic susceptibility to brain cancer
Modeling astrocytomas in a family of inducible genetically engineered mice : implications for preclinical cancer drug development
Human brain tumor cell and tumor tissue transplantation models
Transformed human brain cells in culture as a model for brain tumors
Rat glioma models for preclinical evaluation of novel therapeutic and diagnostic modalities
Neuro-oncogenesis induced by nitroso compounds in rodents and strain-specific genetic modifiers of predisposition
The murine GL261 glioma experimental model to assess novel brain tumor treatments
Spontaneous occurrence of brain tumors in animals: opportunities as preclinical model systems
Part II. Prognostic factors and biomarkers
p53 pathway alterations in brain tumors
The PTEN/P13 kinase pathway in human glioma
Value of 1p/19q and other LOH markers for brain tumor diagnosis, prognosis, and therapy
Discovery of genetic markers for brain tumors by comparative genomic hybridization
Genomic identification of significant targets in brain cancer
Oncomodulatory role of the human cytomegalovirus in glioblastoma
Aberrant EGFR signaling in glioma
Mechanisms of brain tumor angiogenesis
Vaso-occlusive mechanisms that intiate hypoxia and necrosis in glioblastoma: the role of thrombosis and tissue factor
Transcription profiling of brain tumors: tumor biology and treatment stratification
Proteomic profiling of human brain tumors
Proteomic discovery of biomarkers in the cerebrospinal fluid of brain tumor patients
Epigenetic profiling of gliomas
Micronase in the central nervous system and potential roles of RNA interference in brain tumors
Of Escherichia coli and man : understanding glioma resistance to temozolomide therapy
Brain tumor stem cell markers
Part III. Therapeutic targets and targeting approaches
Clinical agents for the targeting of brain tumor vasculature
Bone marrow-derived cells in GBM neovascularization
Vascular targeting of brain tumors
bridging the gap with phage display
Impact of the blood-brain barrier on brain tumor imaging and therapy
Targeting CXCR4 in brain tumors
Molecular targeting of IL-13R[alpha]2 and EphA2 receptor in GBM
Molecular targets for antibody-mediated immunotherapy of malignant glioma
Stat3 oncogenic signaling in glioblastoma multiforme
Inhibition of Ras signaling for brain tumor therapy
HGF/c-Met signaling and targeted therapeutics in brain tumors
Combinatorial therapeutic strategies for blocking kinase pathways in brain tumors
Targeting the TRAIL apoptotic pathways for glioblastoma therapies
The NF-[kappa]B signaling pathway in GBMs : implications for apoptotic and inflammatory responses and exploitation for therapy
Targeting endoplasmic reticulum stress for malignant glioma therapy
Brain cancer stem cells as targets of novel therapies
The use of retinoids as differentiation agents against medulloblastoma
Herpes simplex virus 1 (HSV-1) for glioblastoma multiforme therapy
The development of targeted cancer gene-therapy adenoviruses for high-grade glioma treatment
Harnessing T-cell immunity to target brain tumors
Glioma invasion : mechanisms and therapeutic challenges.

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Tags: Marcela Assanah, Kim A Lopez, Jeffrey N Bruce, Peter Canoll, Erwin G Meir, CNS Cancer, Therapeutic Approaches

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