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Status:
Available5.0
12 reviews
ISBN-10 : 0120066912
ISBN-13 : 9780120066919
Author: George F. Vande Woude, George Klein
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including
Chapter 1. Imatinib as a Paradigm of Targeted Therapies
I. Introduction
II. Identification of the BCR-ABL Tyrosine Kinase as a Therapeutic Target
III. Development of an ABL-Specific Tyrosine Kinase Inhibitor
IV. Clinical Trials in CML
V. Mechanisms of Relapse
VI. Structural Basis of ABL Inhibition by Imatinib
VII. Activity of Imatinib in Other Indications
VIII. Lessons Learned from the Clinical Trials of Imatinib
IX. Translating the Success of Imatinib to Other Malignancies
References
Chapter 2. Prostate Cancer and the Met Hepatocyte Growth Factor Receptor
I. Hepatocyte Growth Factor/Scatter Factor–Met and Stromal–Epithelial Interactions in the Prosta
II. Met in Localized Prostate Cancer
III. Met in Prostate Cancer Metastasis
IV. Therapeutic Implications of Met Expression in Prostate Cancer
References
Chapter 3. Keratinocyte Growth Factor/Fibroblast Growth Factor 7, a Homeostatic Factor with Therapeu
I. Introduction
II. Molecular Biology of KGF
III. Cellular and Molecular Responses to KGF
IV. Signal Transduction
V. Transgenic and Knockout Models
VI. Regenerative and Protective Effects
VII. Clinical Trials. Amelioration of Severe Oral Mucositis
VIII. Concluding Remarks
References
Chapter 4. Histone Deacetylase Inhibitors
I. Chromatin Structure
II. Histone Deacetylases and Histone Acetyltransferases
III. Histone Deacetylases/Histone Acetyltransferases and Human Cancers
IV. Histone Deacetylase Inhibitors
V. Activity of Histone Deacetylase Inhibitors
VI. Clinical Trials with Histone Deacetylase Inhibitors
VII. Conclusions and Perspectives
References
Chapter 5. Raf-1 Kinase Inhibitor Protein. Structure, Function, Regulation of Cell Signaling, and Pi
I. Introduction. The Phosphatidylethanolamine-Binding Protein Family
II. Raf-1 Kinase Inhibitor Protein
III.Sigficance of rkip in Cancer
IV. Concluding Remarks
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Tags: Advances, Cancer Research, George Vande Woude, George Klein
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