(Ebook) Advances in Cancer Research 109 1st edition by George Vande Woude, George Klein 0123808905 9780123808905

(Ebook) Advances in Cancer Research 109 1st edition by George Vande Woude, George Klein 0123808905 9780123808905

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ISBN-10 :  0123808905 

ISBN-13 :  9780123808905 

Author:  George F. Vande Woude, George Klein 

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Advances in Cancer Research 109 1st Table of contents:

Chapter 1: Mechanisms of Prostate Cancer Initiation and Progression
I. Epidemiologic Studies in Prostate Cancer
II. The Architecture of the Normal Prostate Gland
III. Development and Maintenance of the Prostate Gland
IV. Morphological and Cytological Changes that Take Place During Prostate Cancer Initiation and Prog
V. Early Genetic and Epigenetic Events in the Transition from Normal Prostate to PIN and Invasive Ca
VI. Transition to High-Grade Carcinoma and Metastasis
VII. Mechanisms of Castration-Resistant Prostate Cancer
VIII. Summary and Future Directions
Acknowledgments
References
Chapter 2: Genetic Basis for Susceptibility to Lung Cancer: Recent Progress and Future Directions
I. Introduction: Overview of Studies on Genetic and Environmental Factors Involved in Lung Cancer Su
II. Differences in the Process of Lung Cancer Development Between Smokers and Never-Smokers
III. Candidate Gene Association Studies
IV. Genome-Wide Association Studies
V. Assessment of Lung Cancer Risk in Each Individual by Combined Genotypes (Gene-Gene Interactions)
VI. Smoking-Associated Differences (Gene-Environment Interactions)
VII. Necessity of Further Association Studies
VIII. Future Directions
Acknowledgments
References
Chapter 3: Functional and Clinical Relevance of Chondroitin Sulfate Proteoglycan 4
I. Introduction
II. Phylogenetic Evolution, Structure, and Tissue Distribution of CSPG4
III. Functional Properties of CSPG4
IV. Clinical Applications of CSPG4
V. Conclusion
Acknowledgments
References
Chapter 4: KRAS Signaling Pathway Alterations in Microsatellite Unstable Gastrointestinal Cancers
I. Mismatch Repair, MSI, and Related Target Genes
II. MSI-H Phenotype-Related Molecular and Clinicopathologic Features
III. MSI-H-Related Epigenetic Features: CpG island Methylator Phenotype
IV. MSI-H-Related Genetic Features: The KRAS Signaling Pathway
V. A Serrated Carcinogenesis Pathway in the Origin of Sporadic MSI CRC
VI. Conclusions

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