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6 reviewsSUMMARYOvarian aging plays a pivotal role in female reproductive health, with implications for treatment strategies andquality of life. However, the potential of a single pharmaceutical agent to mitigate primate ovarian aging remains largely unexplored. Our 3.3-year study in monkeys demonstrates that oral vitamin C has geroprotective effects against ovarian aging. Vitamin C diminishes key aging biomarkers, including oxidative stress andfollicular depletion. Using a single-cell transcriptomic clock, we show that vitamin C can reduce the biologicalage of oocytes by 1.35 years and somatic cells by 5.66 years. This effect is partly mediated by the NRF2pathway, which alleviates ovarian cell senescence and inflammation. Our findings highlight the role of vitaminC in combating primate ovarian aging and provide insights for developing interventions against humanovarian aging.