USP14/S100A11 axis promote colorectal cancer progression by inhibiting cell senescence by Yong Huang & Xiaolei Tang & Hao Xie & Zhaoying Wu & Lei Jin & Lei Zhang & Xidong Lin & Hailang Zhou & Junwei Zou instant download

USP14/S100A11 axis promote colorectal cancer progression by inhibiting cell senescence by Yong Huang & Xiaolei Tang & Hao Xie & Zhaoying Wu & Lei Jin & Lei Zhang & Xidong Lin & Hailang Zhou & Junwei Zou instant download

The aberrant expression of S100A11 has been identified in various malignancies but its functional roles and underlying mechanisms incolorectal cancer (CRC) have not been fully elucidated. Therefore, this study was designed to investigate the expression of S100A11 andits functional significance in CRC, indicating that S100A11 is significantly upregulated and correlates with poor survival outcomes in CRC.Functionally, S100A11 knockdown in CRC cell lines inhibited cell proliferation, invasion, and migration, leading to decreased tumourgrowth and metastasis in vivo. Mechanistic investigations revealed that S100A11 promotes cell proliferation and invasion by suppressingcell senescence. In addition, USP14 interacts with and mediates S100A11 deubiquitination. More importantly, the overexpression ofS100A11 was able to partially counteract the reduction in cell proliferation caused by the knockdown of USP14. In summary, the novelregulatory axis involving USP14 and S100A11 modulates the malignant biological behavior of CRC cells through inhibiting cell1234567890();,:senescence, therefore the interaction between USP14 and S100A11 represents a promising therapeutic target in CRCCell Death and Disease (2025) 16:384 ;