Most ebook files are in PDF format, so you can easily read them using various software such as Foxit Reader or directly on the Google Chrome browser.
Some ebook files are released by publishers in other formats such as .awz, .mobi, .epub, .fb2, etc. You may need to install specific software to read these formats on mobile/PC, such as Calibre.
Please read the tutorial at this link. https://ebooknice.com/page/post?id=faq
We offer FREE conversion to the popular formats you request; however, this may take some time. Therefore, right after payment, please email us, and we will try to provide the service as quickly as possible.
For some exceptional file formats or broken links (if any), please refrain from opening any disputes. Instead, email us first, and we will try to assist within a maximum of 6 hours.
EbookNice Team
Status:
Available0.0
0 reviewsSUMMARYEpithelial tissues serve as the first line of host against bacterial infections. The self-organization of epithelialtissues continuously adapts to the architecture and mechanics of microenvironments, thereby dynamicallyimpacting the initial niche of infections. However, the mechanism by which tissue geometry regulates bacterial infection remains poorly understood. Here, we showed geometry-guided infection patterns of bacteria inepithelial tissues using bioengineering strategies. We discovered that cellular traction forces play a crucialrole in the regulation of bacterial invasive sites and marginal infection patterns in epithelial monolayersthrough triggering co-localization of mechanosensitive ion channel protein Piezo1 with bacteria. Further,we developed precise mechanobiology-based strategies to potentiate the antibacterial efficacy in animalmodels of wound and intestinal infection. Our findings demonstrate that tissue geometry exerts a key impacton mediating spatiotemporal infections of bacteria, which has important implications for the discovery anddevelopment of alternative strategies against bacterial infections.