(Ebook) Thiamine Catalytic Mechanisms in Normal and Disease States 1st Edition by Frank Jordan, Mulchand S Patel ISBN 0824740629 9780824740627

(Ebook) Thiamine Catalytic Mechanisms in Normal and Disease States 1st Edition by Frank Jordan, Mulchand S Patel ISBN 0824740629 9780824740627

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ISBN 10: 0824740629 
ISBN 13: 9780824740627
Author: Frank Jordan, Mulchand S Patel

Compiling landmark research from those laying the foundation for medical science's next leap forward, Thiamine: Catalytic Mechanisms in Normal and Disease States fully explores the pathophysiological aspects of a spectrum of diseases associated with TDP-requiring enzymes. Providing brilliant new insights into neurogenerative diseases, this comprehensive volume associates defects in the function of TDP-dependent enzymes with numerous metabolic disorders and disease states, and offers novel aspects of thiamine enzymes in chiral synthesis, as well as new perspectives on the cellular role of thiamine triphosphate and thiamine triphosphates.

(Ebook) Thiamine Catalytic Mechanisms in Normal and Disease States 1st Table of contents:

1. Chemical Intermediates in Catalysis by Thiamine Diphosphate

2. Mechanistic and Structural Studies on Thiamine Biosynthetic Enzymes

3. Studies on the Structure and Function of Thiamine Pyrophosphokinase

4. New Perspectives on the Cellular Role of Thiamine Triphosphate and Thiamine Triphosphatase

5. How Thiamine Works in Enzymes: Time-Resolved NMR Snapshots of TDP-Dependent Enzymes in Action

6. Thiamine-Dependent Enzymes as Catalysts of C–C Bond-Forming Reactions: The Role of “Orphan” Enzymes

7. Ligand-Induced Conformational Changes in Thiamine Diphosphate-Dependent Enzymes: Comparison Between Crystal and Solution Structures

8. Enantioselective Syntheses of Hydroxy Ketones via Benzoylformate Decarboxylase- and Benzaldehyde Lyase-Catalyzed C–C Bond Formation

9. Benzoylformate Decarboxylase: Lessons in Enzymology

10. New Concept on the Nature of the Induced Absorption Band of Holotransketolase

11. Structure of the α-Carbanion/Enamine Reaction Intermediate in the Active Site of Transketolase, Determined by Kinetic Crystallography

12. Yeast Pyruvate Decarboxylase: New Features of the Structure and Mechanism

13. Solvent and Carbon Kinetic Isotope Effects on Active-Site and Regulatory-Site Variants of Yeast Pyruvate Decarboxylase

14. Insights into the Mechanism and Regulation of Bacterial Acetohydroxyacid Synthases

15. Structure and Properties of Acetohydroxyacid Synthase

16. Exploring the Substrate Specificity of Benzoylformate Decarboxylase, Pyruvate Decarboxylase, and Benzaldehyde Lyase

17. Benzoylformate Decarboxylase: Intermediates, Transition States, and Diversions

18. Structural and Functional Organization of Pyruvate Dehydrogenase Complexes

19. The Pyruvate Dehydrogenase Multienzyme Complex

20. Activation and Transfer of Lipoic Acid in Protein Lipoylation in Mammals

21. Central Organization of Mammalian Pyruvate Dehydrogenase (PD) Complex and Lipoyl Domain-Mediated Activated Function and Control of PD Kinases and Phosphatase 1

22. Physiological Effects of Replacing the PDH Complex of E. coli by Genetically Engineered Variants or by Pyruvate Oxidase

23. Structure and Intersubunit Information Transfer in the E. coli Pyruvate Dehydrogenase Multienzyme Complex

24. Structure, Function, and Regulation of Pyruvate Dehydrogenase Kinase

25. Three-Dimensional Structures for Components and Domain of the Mammalian Branched-Chain α-Ketoacid Dehydrogenase Complex

26. Variability of Human Pyruvate Dehydrogenase Complex Deficiency

27. Kinetic Studies of Human Pyruvate Dehydrogenase and Its Mutants: Interactions with Thiamine Pyrophosphate

28. The Complexity of Single-Gene Disorders: Lessons from Maple Syrup Urine Disease and Thiamine Responsiveness

29. Thiamine Pyrophosphate: An Essential Cofactor in the Mammalian Metabolism of 3-Methyl-Branched Fatty Acids

30. Pathogenesis of Selective Neuronal Loss in Wernicke-Korsakoff Syndrome: Role of Oxidative Stress

31. Thiamine-Responsive Megaloblastic Anemia Syndrome: Clinical Aspects and Molecular Genetics

32. Accomplishments and Future Directions

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Tags: Frank Jordan, Mulchand S Patel, Thiamine, Catalytic