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0 reviewsCannabis has been consumed for centuries, but global regulatory Introductionchanges over the past three decades have increased the availability and Cannabis regulationconsumption of cannabis. Cannabinoids are touted to have therapeutic The endocannabinoid systempotential for many diseases and could be a replacement for opioids for Cannabinoid receptor analgesia and sedation. However, cannabinoids can cause substantial therapeuticsadverse cardiovascular events that would mitigate any potential Cardiovascular risk factorsbeneft. The endocannabinoid system regulates mood, satiety and Cardiovascular diseasesmemory, and modulates the cardiovascular system. The link between cannabinoids and cardiovascular disease, which used to be limited Types of cannabinoids and their usesto evidence from preclinical studies, case reports and case series, Gateway drugis now evident in epidemiological studies. Cannabinoids adversely afect the cardiovascular system, causing myocardial infarction, Conclusionscerebrovascular accidents, arrhythmia and heart failure. The efects of novel cannabinoids are unknown, and synthetic cannabinoids have the potential to cause even more substantial harm than traditional cannabinoids. Therefore, with the increasing availability and use of cannabis, the acute and chronic efects of this drug are becoming apparent.