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17 reviewsExecutive summary including HBV, HCV, metabolic dysfunction-associated Published OnlineJuly 28, 2025Liver cancer is the sixth most common cancer and the steatotic liver disease (MASLD), and alcohol. The clear leading cause of cancer-related mortality globally. and unique causes of hepatocellular carcinoma present S0140-6736(25)01042-6The number of new liver cancers will nearly double, from valuable opportunities for cancer prevention through *Equally contributing authors0·87 million in 2022 to 1·52 million in 2050, if there is no medical treatment and lifestyle changes. In particular, State Key Laboratory of change in the current trend. Hepatocellular carcinoma, hepatocellular carcinoma frequently develops in Translational Oncology, the most prevalent histological subtype of liver cancer, individuals with cirrhotic liver following a prolonged Department of Clinical accounts for approximately 80% of all primary liver Oncology, Sir Yue-Kong Pao period of chronic liver disease. This feature allows for the Centre for Cancer, The Hong cancers. In response to this issue, a Commission effective implementation of preventive strategies before Kong Cancer Institute, The comprising a broad spectrum of experts in clinical the onset of cancer.Chinese University of Hong medicine and public health was established with the Based on new data and existing evidence, we identified Kong, Hong Kong Special primary objective of addressing the rising disease burden Administrative Region, Chinathe current challenges for addressing the hepatocellular (Prof S L Chan MD, of hepatocellular carcinoma. We undertook a systematic carcinoma burden and formulated ten recommendations. L L Chang MBChB); Department process of idea generation, literature review, evidence For preventive strategies, there are established and of Hepatobiliary Surgery and scoping, novel data synthesis, and modelling, as well as effective measures, including HBV vaccin
4.7
9 reviews