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(Ebook) The hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome by Novartis Foundation Symposium ISBN 9780470021408, 0470021403

  • SKU: EBN-1342638
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Instant download (eBook) The hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome after payment.
Authors:Novartis Foundation Symposium
Pages:308 pages.
Year:2005
Editon:1
Publisher:Wiley
Language:english
File Size:5.2 MB
Format:pdf
ISBNS:9780470021408, 0470021403
Categories: Ebooks

Product desciption

(Ebook) The hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome by Novartis Foundation Symposium ISBN 9780470021408, 0470021403

This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding.  It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks.  Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.
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