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Available4.7
37 reviews
ISBN 10: 0120398591
ISBN 13: 9780120398591
Author: Thomas J Chambers, Thomas P Monath, Karl Maramorosch, Aaron J Shatkin, Frederick A Murphy
Chapter 1. Taxonomy of the Virus Family Flaviviridae
I. Historical Perspective
II. Early Classification
III. Toward an Adequate Taxonomy
IV. Current Taxonomic Placement of Flaviviruses
References
Part 1: Structure and Replication
Chapter 2. Molecular Biology of Flaviviruses
I. Introduction
II. Viral Life Cycle
III. Flavivirus Particles
IV. Genome Structure
V. Virus Proteins
VI. RNA Replication
References
Chapter 3. Flavivirus Structure and Membrane Fusion
Preamble
I. Introduction
II. Assembly and Maturation
III. Structure of the E Protein
IV. Architecture of Recombinant Subviral Particles and Virions
V. Fusion Characteristics
VI. Low pH-Induced Structural Changes
VII. Interactions with Membranes
VIII. Function of the prM Protein
IX. Comparative Aspects of the Flavivirus Fusion Machinery
References
Addendum
References for Addendum
Chapter 4. Kunjin RNA Replication and Applications of Kunjin Replicons
I. Introduction
II. Foundations for Developing a Model of KUNV RNA Synthesis
III. Extending the Scope of Replication Analyses
IV. Ultrastructure of Induced Membranes, Their Association with the Replication Complex (RC), and Th
V. Molecular Approaches to Study Formation and Operation of the RC
VI. Development of the Kunjin Replicon Expression System for Vaccines and Gene Therapy.
VII. Concluding Remarks
References
Chapter 5. Antigenic Structure of Flavivirus Proteins
I. Introduction
II. Classical Flavivirus Serology
III. B-Cell Epitopes
IV. T-Cell Epitopes
V. Conclusion
References
Chapter 6. 5'- and 3' -Noncoding Regions in Flavivirus RNA
I. Introduction
II. Conserved Linear Sequence Features of NCRs in Flavivirus RNA
III. Secondary Structure of NCRs.
IV. Mutational Changes in the 5' or 3' NCR and the 3' SL May Result in Attenuation of Virus Virulenc
V. Hypothesis for Hydrogen Bonding between 5' and 3' NCRs
VI. Additional Secondary Structure Predictions in the 3' NCR
VII. Summary and Future Directions
References
Chapter 7. Manipulation of Cell Surface Macromolecules by Flaviviruses
I. Introduction
II. The Flavivirus Receptor Binding Protein
III. Cell Targets for Flaviviruses
IV. Cell Surface Macromolecules Involved in Flavivirus Attachment
V. Cell Surface Macromolecules Modulated by Flavivirus Infection
VI. Other Cell Surface Macromolecular Modifications Triggered by Flavivirus Infection
VII. Conclusions
References
Part 2: Flavivirus Evolution
Chapter 8. Origins, Evolution, and Vector/Host Coadaptations Within the Genus Flavivirus
I. Introduction
II. Phylogenetic Analysis of the Genus Flavivirus
III. Impact of Host/Virus Coadaptation on Flavivirus Evolution
IV. What Are the Origins of Flaviviruses?
V. Does Recombination Occur between Flaviviruses and, if so, What Is the Likely Impact?
References
Chapter 9. Microevolution and Virulence of Dengue Viruses
I. Introduction
II. Genetic Variation within Dengue Serotypes
III. Phylogenetics of Dengue Viruses
IV. Viral Determinants of Disease
V. Viral Determinants of Transmission
VI. Viral Displacement and Epidemiology
flavivirus genome replication involves which two processes
structurally the simplest virus is a/n
which of the following resembles flaviviruses in structure and organisation
label the structures of bacteriophage t4
flavivirus replication complex
Tags: Thomas J Chambers, Thomas P Monath, Karl Maramorosch, Aaron J Shatkin, Frederick A Murphy, Flaviviruses Structure, Structure Replication
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