Taurocholic acid ameliorates hypertension through the activation of TGR5 in the hypothalamic paraventricular nucleus by Ying Li, Ya-Nan Gao, Ying-Bao Zhu, Wen-Fang Lu, Jia-Yue Yu, Yuan-Yuan Dong, Meng-Yue Xu, Bo Peng, Jun-Zhe Wu, Qing Su, Juan Bai, Xiao-Lian Shi, Yu-Ming Kang, Hong-Bao Li, Meng-Lu Xu ISBN 101039/D4FO00808A instant download

Taurocholic acid ameliorates hypertension through the activation of TGR5 in the hypothalamic paraventricular nucleus by Ying Li, Ya-Nan Gao, Ying-Bao Zhu, Wen-Fang Lu, Jia-Yue Yu, Yuan-Yuan Dong, Meng-Yue Xu, Bo Peng, Jun-Zhe Wu, Qing Su, Juan Bai, Xiao-Lian Shi, Yu-Ming Kang, Hong-Bao Li, Meng-Lu Xu ISBN 101039/D4FO00808A instant download

Diets rich in taurine can increase the production of taurine-conjugated bile acids, which are known toexert antihypertensive effects. Despite their benefits to the heart, kidney and arteries, their role in thecentral nervous system during the antihypertensive process remains unclear. Since hypothalamic paraventricular nucleus (PVN) plays a key role in blood pressure regulation, we aimed to investigate the functionof bile acids in the PVN. The concentration of bile acids in the PVN of spontaneously hypertensive rats(SHRs) and normotensive Wistar-Kyoto rats (WKY) fed with normal chow was measured using LC-MS/MS,which identified taurocholic acid (TCA) as the most down-regulated bile acid. To fully understand themechanism of TCA’s functions in the PVN, bi-lateral PVN micro-infusion of TCA was carried out. TCAtreatment in the PVN led to a significant reduction in the blood pressure of SHRs, with decreased plasmalevels of norepinephrine and improved morphology of cardiomyocytes. It also decreased the number ofc-fos+ neurons, reduced the inflammatory response, and suppressed oxidative stress in the PVN of theSHRs. Most importantly, the TGR5 receptors in neurons and microglia were activated. PVN infusion ofReceived 19th February 2024,SBI-115, a TGR5 specific antagonist, was able to counteract with TCA in the blood pressure regulation ofAccepted 10th April 2024SHRs. In conclusion, TCA supplementation in the PVN of SHRs can activate TGR5 in neurons and microDOI: 10.1039/d4fo00808aglia, reduce the inflammatory response and oxidative stress, suppress activated neurons, and attenuatersc.li/food-functionhypertension.