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(Ebook) Target Validation in Drug Discovery by Brian W. Metcalf, Susan Dillon ISBN 9780123693938, 0123693934

  • SKU: EBN-2401512
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4.5

30 reviews
Instant download (eBook) Target Validation in Drug Discovery after payment.
Authors:Brian W. Metcalf, Susan Dillon
Pages:293 pages.
Year:2006
Editon:1
Publisher:Academic Press
Language:english
File Size:2.11 MB
Format:pdf
ISBNS:9780123693938, 0123693934
Categories: Ebooks

Product desciption

(Ebook) Target Validation in Drug Discovery by Brian W. Metcalf, Susan Dillon ISBN 9780123693938, 0123693934

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.
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