Solid-State Materials in Pharmaceutical Chemistry: Properties, Characterization, and Applications by Stephen R. Byrn, George Zografi, Xiaoming Chen (Sean) ISBN 9781394254446, 139425444X instant download

Solid-State Materials in Pharmaceutical Chemistry: Properties, Characterization, and Applications by Stephen R. Byrn, George Zografi, Xiaoming Chen (Sean) ISBN 9781394254446, 139425444X instant download

The global impact of the COVID-19 pandemic, while mitigated by the rapid development of nucleotide-based vaccines, underscored the critical importance of understanding and controlling the solid-state properties of biopharmaceuticals and advanced delivery systems like lipid nanoparticles, particularly in relation to stability and storage. Moreover, the trend toward larger, poorly water-soluble, small-molecule drugs has positioned amorphous dispersions as a default formulation strategy, demanding innovative approaches to leverage solid-state material science for the development of high-quality active pharmaceutical ingredients (APIs) and stable drug products. The increasing demand for drug-device combination products for self-administration and diagnostics has further underlined the importance of compatibility studies and the interplay between material properties and device performance. Furthermore, the pharmaceutical industry has grappled with the withdrawal of life-saving drugs due to nitrosamine contamination, highlighting the urgent need for advanced analytical techniques and mitigation strategies.