Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury by Mingran Luo, Jiayun Liu, Yunxin Su, Tao Jiang, Xincan Wu, Peng Gao, Tao Qin, instant download

Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury by Mingran Luo, Jiayun Liu, Yunxin Su, Tao Jiang, Xincan Wu, Peng Gao, Tao Qin, instant download

Spinal cord injury (SCI) substantially affects functional capacity and thepatients. Approximately 17 000 new casesare reported annually, with a prevalence ofimmune system plays a crucial role in recovery. Examining alterations in54 new SCI cases per million individuals inthe United States and≈6.4 cases per millionmicroglia metabolism can lead to improved repair mechanisms; however, thein China.[1] Patients with SCI often have amolecular subtyping of microglia lacks consensus. In this study, the effects ofpoor prognosis and endure lifelong disabilSCI on macrophages and microglia in mice are investigated to identify tailoredity due to the limited regenerative capabiltherapeutic targets and interventions for patients with SCI. Macrophagesities of the central nervous system (CNS).infiltrate the spinal cord shortly after injury; however, infiltration decreasesFurthermore, the immune response mayover time. Microglial phagocytosis of myelin debris is associated withincreased lipid accumulation. Macrophage deletion improves outcomes,whereas microglial deletion worsens them. The PLIN2+ microglia subtype inlipid droplet formation shows abnormal activation of the Pparg signalingpathway compared with that with other subtypes. PPARG promotes lipidmetabolism and recovery, and atorvastatin (a PPARG agonist) reverses alteredmetabolic processes. Macrophages and microglia play complex roles in SCI.Targeting PPARG and its agonists is a promising therapeutic approach for SCI.