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ISBN 10: 0121827860
ISBN 13: 9780121827861
Author: Sies Helmut, Packer Lester
Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers more clinical aspects of quinines, such as anticancer properties, as well as their role in nutrition and in age-related diseases.
I. Mitochondrial Ubiquinone and Reductases
1. Mitochondrial Quinone Reductases: Complex I
2. Q-Cycle Bypass Reactions at the Qo Site of the Cytochrome bc1 (and Related) Complexes
3. Targeting Coenzyme Q Derivatives to Mitochondria
4. The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia
5. Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency
6. Coenzyme Q Cytoprotective Mechanisms
7. Dietary Coenzyme Q10 and Mitochondrial Status
II. Anticancer Quinones and Quinone Oxidoreductases
8. NAD(P)H:Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics
9. Structure and Mechanism of NAD[P]H:Quinone Acceptor Oxidoreductases (NQO)
10. Diaziridinylbenzoquinones
11. Quinone Reductase–Mediated Nitro-Reduction: Clinical Applications
12. Bioactivation and Resistance to Mitomycin C
13. NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase in HeLa Cells
14. The “Prochaska” Microtiter Plate Bioassay for Inducers of NQO1
15. Structure-Activity Relationships in Two-Electron Reduction of Quinones
16. p53-Dependent Apoptosis and NAD(P)H:Quinone Oxidoreductase 1
17. The Role of Endogenous Catechol Quinones in the Initiation of Cancer and Neurodegenerative Diseases
18. Induction of NQO1 in Cancer Cells
III. Quinone Reductases: Chemoprevention and Nutrition
19. Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection against Toxicity of Electrophiles and Reactive Oxygen Intermediates
20. Activation and Detoxification of Naphthoquinones by NAD(P)H: Quinone Oxidoreductase
21. Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens
22. Chemoprevention by 1,2-Dithiole-3-Thiones Through Induction of NQO1 and Other Phase 2 Enzymes
23. Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)
24. Induction of Phase II Enzymes by Aliphatic Sulfides Derived from Garlic and Onions: An Overview
25. Upregulation of Quinone Reductase by Glucosinolate Hydrolysis Products From Dietary Broccoli
IV. Quinones and Age-Related Diseases
26. Therapeutic Effects of Coenzyme Q10 in Neurodegenerative Diseases
27. Neuroprotective Actions of Coenzyme Q10 in Parkinson's Disease
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Tags: Sies Helmut, Packer Lester, Quinones, Quinone Enzymes, Part B
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