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11 reviewsColorectal cancer (CRC) is the third most common cancer and remains a significant challenge due to high rates of drug resistanceand limited therapeutic options. Circular RNAs (circRNAs) are increasingly recognized for their roles in CRC initiation, progression,and drug resistance. However, no circRNA-based therapies have yet entered clinical development, underscoring the need forcomprehensive detection and mechanistic studies of circRNAs in CRC. Here, we identified and characterized a circular RNA,circ_0001766 (hsa_circ_0001766), through microarray analysis of CRC tissues. Our results showed that circ_0001766 is1234567890();,:downregulated in CRC tissues and closely associated with patient survival and metastasis. Functional experiments demonstratedthat circ_0001766 inhibits CRC cell proliferation, migration and invasion both in-vitro and in-vivo. Mechanistically, hypoxiadownregulates Quaking (QKI), an RNA-binding protein essential for the biogenesis of circ_0001766 by binding to introns 1 and 3 ofPDIA4 pre-mRNA. Reduced QKI expression under hypoxic conditions leads to decreased circ_0001766 levels in CRC. Circ_0001766acts as a competitive endogenous RNA, sponging miR-1203 to prevent the degradation of PPP1R3C mRNA. Loss of circ_0001766results in decreased PPP1R3C expression, leading to the activation of mTOR signaling and increased phosphorylation of Myc, whichpromotes CRC progression and rapamycin resistance. Our study reveals that overexpression of circ_0001766 or PPP1R3C in CRC cellsinhibits the mTOR and Myc pathway, thereby resensitizing cells to rapamycin. The combination of circ_0001766 or PPP1R3C withrapamycin markedly inhibits CRC cell proliferation and induces apoptosis by reducing rapamycin-induced Myc phosphorylation. Insummary, our study elucidates a critical circ_0001766/miR-1203/PPP1R3C axis that modulates CRC progression and rapamycinresistance. Our findings highlight circ_0001766 as a promising therapeutic target in CRC, providing a new avenue for enhancing theefficacy of existing treatments and overcoming drug resistance.Cell Death Discovery (2025) 11:192 ;