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EbookNice Team
Status:
Available4.7
38 reviewsBackground: Cognitive impairment is often reported after SARS-CoV-2 infection, yet evidence
gaps remain. We aimed to (i) report the prevalence and characteristics of children and young
people (CYP) reporting “brain fog” (i.e., cognitive impairment) 12-months post PCR-proven SARS-
CoV-2 infection and determine whether differences by infection status exist and (ii) explore the
prevalence of CYP experiencing cognitive impairment over a 12-month period post-infection and
investigate the relationship between cognitive impairment and poor mental health and well-
being, mental fatigue and sleep problems.
Methods: The Omicron CLoCk sub-study, set up in January 2022, collected data on first-time PCR-
test-positive and PCR-proven reinfected CYP at time of testing and at 3-, 6- and 12-months post-
testing. We describe the prevalence of cognitive impairment at 12-months, indicating when it
was first reported. We characterise CYP experiencing cognitive impairment and use chi-squared
tests to determine whether cognitive impairment prevalence varied by infection status. We
explore the relationship between cognitive impairment and poor mental health and well-being,
mental fatigue and trouble sleeping using validated scales. We examine associations at 3-, 6- and
12-months post-testing by infection status using Mann-Whitney U and chi-square tests.
Results: At 12-months post-testing, 7.0% (24/345) of first-positives and 7.5% (27/360) of
reinfected CYP experienced cognitive impairment with no difference between infection-status
groups (p=0.78). The majority of these CYP experienced cognitive impairment for the first time at
either time of testing or 3-months post-test (no difference between the infection-status groups;
p=0.60). 70.8% of first-positives experiencing cognitive impairment at 12-months, were 15-to-17-
years-old as were 33.3% of reinfected CYP experiencing cognitive impairment (p<0.01).
Consistently at
…