(Ebook) Predictive Toxicology in Drug Safety by Jinghai J. Xu, Laszlo Urban ISBN 9780511909993, 9780521763646, 0521763649, 0511909993

(Ebook) Predictive Toxicology in Drug Safety by Jinghai J. Xu, Laszlo Urban ISBN 9780511909993, 9780521763646, 0521763649, 0511909993

According to the Institute of Medicine (IOM) and U.S. Food and Drug Administration (FDA), ''developing new scientific approaches to detecting, understanding, predicting, and preventing adverse events'' was a critical path to the future of drug safety. This book brings together a collection of state-of-the-art chapters, written by experts in the drug safety field. It provides information on the present knowledge of drug side effects and their mitigation strategy during drug discovery, gives guidance for risk assessment, and promotes evidence-based toxicology. Each specific area of toxicology relevant for drug discovery is discussed in detail, including theory, experimental approaches, and data interpretation supported by comprehensive up-to-date references. Many chapters provide fascinating case studies, which are of general interest for those who have basic science training and are interested in how chemicals interact with the human body.