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9 reviewsIn predictive coding (PC), higher-order brain areas generate predictions that are Highlights sent to lower-order sensory areas. Top-down predictions are compared with botPredictive coding (PC) models propose tom-up sensory data, and mismatches evoke prediction errors. In PC, the predicthat predictions are generated in higherorder areas and feed back to lowertion errors are encoded in layer 2/3 pyramidal neurons of sensory cortex that feed order areas, where they are compared forward. The PC model has been tested with multiple recording modalities using with sensory inputs. Mismatches generthe global–local oddball paradigm. Consistent with PC, neuroimaging studies reate prediction errors. ported prediction error responses in sensory and higher-order areas. However, The local–global oddball paradigm is recent studies of neuronal spiking suggest that genuine prediction errors emerge used to study PC. Local oddballs are in prefrontal cortex (PFC). This implies that predictive processing is a more cogformed from repetition-based predicnitive than sensory-based mechanism – an observation that challenges PC and tions and do not necessarily imply a prebetter aligns with a framework we call predictive routing (PR).