Potential Transmission of Alpha-Synuclein from the Gastrointestinal Tract to the Substantia Nigra along the Vagal Afferent Pathway by Fan Han & Meiqiu Liu & Qian Jiao & Xixun Du & Chunling Yan & Xi Chen & Hong Jiang instant download

Potential Transmission of Alpha-Synuclein from the Gastrointestinal Tract to the Substantia Nigra along the Vagal Afferent Pathway by Fan Han & Meiqiu Liu & Qian Jiao & Xixun Du & Chunling Yan & Xi Chen & Hong Jiang instant download

Neuroscience Bulletin,Abstract Parkinson’s disease (PD) is characterised by Keywords Parkinson’s disease · α-Synuclein · Vagal dopaminergic (DA) neuron loss and the formation of Lewy aferents · Dorsal motor nucleus of the vagus · Substantia bodies composed of aggregated α-synuclein (α-Syn) in the nigra · Capsaicinsubstantia nigra (SN). Emerging evidence suggests that PD may originate in the gastrointestinal (GI) tract, where α-Syn aggregates in enteroendocrine cells that synapse with vagal Introductionaferents, facilitating disease spread to the central nervous system. Using electrophysiological, behavioural, molecuParkinson’s disease (PD) is the second most common lar, and immunohistochemical methods, we examined the neurodegenerative disease [1]. PD patients present motor efects of capsaicin-induced degeneration of vagal aferents symptoms such as resting tremor, rigidity, and bradykinesia on PD progression in models: one was prepared by inject[2]. The typical pathological characteristics of PD involve ing α-Syn preformed fbrils into the GI tract, and the other gradual degeneration of dopaminergic (DA) neurons in the was prepared by orally administering rotenone. The results substantia nigra (SN) pars compacta and the formation of showed that vagal aferents mediate GI sensory signals Lewy bodies, which are primarily composed of aggregated afecting DA and GABA neurons in the SN. Vagal aferalpha-synuclein (α-Syn) [3]. According to Braak’s staging ent degeneration reduces α-Syn accumulation in the dorsal hypothesis, PD may originate in the gastrointestinal (GI) motor nucleus of the vagus and SN while improving motor tract, where it progressively spreads from the enteric nervimpairments, highlighting their role in α-Syn transmission ous system through the dorsal motor nucleus of the vagus and PD pathogenesis.(DMV) in the brainstem to eventually reach the SN [4–6], where α-Syn spreads from cell to cell in a prion-like manner