(Ebook) Polymeric Drug Delivery Systems 1st Edition by Glen S Kwon ISBN 0824725328 9780824725327

(Ebook) Polymeric Drug Delivery Systems 1st Edition by Glen S Kwon ISBN 0824725328 9780824725327

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Product details:

ISBN 10: 0824725328

ISBN 13: 9780824725327 

Author: Glen S. Kwon 

Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.

Table of contents:

N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates

Ruth Duncan

Background

HPMA Copolymer Conjugates—An Historical Perspective

Synthesis and Characterization of HPMA Copolymer Conjugates

Biological Rationale for Design and Potential Applications

Clinical Status of HPMA Copolymer Conjugates

Other Applications

Related Technologies

Future Prospects

Functional PEG for Drug Delivery

Motoi Oishi, Yukio Nagasaki, and Kazunori Kataoka

Introduction

Synthesis of Heterotelechelic Poly(ethylene Glycol)s

Synthesis of an End-Functionalized Block Copolymer Possessing a PEG Segment

Bioconjugation Using Heterotelechelic PEG

Functionalized Polymeric Micelles by a Self-Assemblingof End-Functionalized PEG Block Copolymers

Conclusion

pH-Sensitive Polymers for Drug Delivery

Kun Na and You Han Bae

Introduction

pH Variation in the Body

pH-Sensitive Polymers

Oral Delivery

Parenteral Drug Carriers

Conclusion

Hydrogels for Oral Administration

Seong Hoon Jeong, Yourong Fu, and Kinam Park

Introduction

Application of Hydrogels in Oral Drug

Delivery

Hydrogels for Specific Applications

Hydrogels for the Controlled Release of Proteins

Wim E. Hennink, Cornelus F. van Nostrum, Daan J. A. Crommelin, and Jeroen M. Bezemer

Introduction

Hydrogels: General Features

Dextran Hydrogels as Protein-Releasing Matrices

Amphiphilic Poly(ether Ester) Multiblock Copolymers as Protein-Releasing Matrices

The Stability of Hydrogel-Associated Pharmaceutical Proteins

Concluding Remarks

Thermosensitive Biodegradable Hydrogels for the Delivery of Therapeutic Agents

Young Min Kwon and Sung Wan Kim

Introduction

Poly(N-Isopropylacrylamide) and Its Copolymers

PEO-PPO-PEO Triblock Copolymers

Thermosensitive and Biodegradable Polymer Hydrogels

Biodegradable Microspheres Based on the Thermosensitive Property of PLGA-PEG-PLGA

Conclusions

Hydrogels: Stimuli-Sensitive Hydrogels

Akihiko Kikuchi and Teruo Okano

Introduction

Stimuli-Responsive Hydrogels and Their Applications in Drug Delivery Systems

Conclusions

Treatment of Malignant Brain Tumors with Controlled-Release Local-Delivery Polymers . .

Alex A. Khalessi, Paul P. Wang, Robert S. Langer, and Henry Brem

Introduction

Drug Delivery Considerations in the CNS

Biocompatible Polymer Development: An Historical Perspective

Clinical Applications of Polyanhydride Polymers for Intracranial Drug Delivery

Future Directions

Conclusions

Improving the Stability of PLGA-Encapsulated Proteins

Steven P. Schwendeman and Jichao Kang

Overview and Historical Perspective

Evidence of Protein Instability

What Is the Instability Pathway?

Examples of Stabilizing PLGA-Encapsulated Proteins

Concluding Remarks

Recombinant Polymers for Drug Delivery

Zaki Megeed and Hamidreza Ghandehari

Introduction

Synthesis and Characterization

Drug Delivery Applications

Gene Delivery Applications

Tissue Repair Applications

Biocompatibility and Biodegradation

Conclusions

Polymeric Nanoparticle Delivery of Cancer Vaccines

John Samuel and Glen S. Kwon

Introduction

Cancer Vaccines: Promise and Problems

Critical Issues in Cancer Vaccine Delivery

Cancer Vaccine Delivery: Living vs. Non-Living Systems

PLGA-Based Pharmaceutical Delivery Systems

‘‘Pathogen Mimicking’’ Nanoparticles for Cancer Vaccines

Concluding Remarks

Polymer Assemblies: Intelligent Block Copolymer Micelles for the Programmed Delivery of Drugs and Genes

Younsoo Bae and Kazunori Kataoka

Introduction

Rationale for Delivery System Using Polymer Assemblies

Block Copolymer Micelles for Drug Delivery

Block Copolymer Micelles for the Delivery of Genes and Charged Materials

Programmed Delivery Using Block Copolymer Micelles

Future Prospects of Block Copolymer Micelles

Polymeric Micelles for the Targeting of Hydrophobic Drugs

Masayuki Yokoyama

Polymeric Micelles for Drug Carriers

The History of Polymeric Micelle Drug Carriers

The Molecular Design of Polymeric Micelle Drug Carrier Systems

Examples of Drug Targeting with Polymeric Micelle Carriers

Pluronic_ Block Copolymers for Drug and Gene Delivery

Alexander V. Kabanov and Jian Zhu

Introduction

Pluronic Structure and Synthesis

Self-Assembly of Pluronic Block Copolymers

Pluronic_ Formulations for Treatment of Drug-Resistant Tumors

Pluronic Effects on Brain and Oral Bioavailability of Drugs

Optimization of Pluronic Composition for PGP Inhibition

Pluronic Block Copolymers for Gene Therapy

Graft Copolymers for Therapeutic Gene Delivery

Anurag Maheshwari, James W. Yockman, and Sung Wan Kim

Non-viral gene Therapy

Nomenclature of Graft Copolymers

Cationic Graft Copolymers

Biodegradable and Targetted Polymeric Gene Carriers

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Tags: Glen S Kwon, Polymeric, Drug, Delivery, Systems