Pathogen Genomics Impact on Human Health 1st edition by Karen Joy Shaw ISBN 1592591728 9781468496833

Pathogen Genomics Impact on Human Health 1st edition by Karen Joy Shaw ISBN 1592591728 9781468496833

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ISBN 10: 1592591728
ISBN 13: 9781468496833
Author: Karen Joy Shaw

Leading infectious disease researchers and pharmaceutical scientists comprehensively review the latest genomic technologies and their application to the prevention, diagnosis, and treatment. The authors' cross-disciplinary approach, with expertise acquired from studying disease-causing viruses, bacteria, fungi, and protozoa, reveals how sequence information from diverse pathogens has uncovered novel targets for drug discovery, antigenic determinants for vaccine development, as well as diagnostic tools. The authors also discuss the application of DNA micoarrays and the impact of genome sequencing comparisons on the discovery and choices of novel drug targets. The result is a better understanding how genomic information can reveal the fundamentals of microbial pathogenesis and how organisms interact with their host environment.

Pathogen Genomics: Impact on Human Health 1st Table of contents:

I Viruses

1 Antiviral Drug Target Discovery with DNA Microarrays

INTRODUCTION

VIRUS DNA ARRAYS

USING MICROARRAYS TO STUDY CHANGES IN THE HOST-CELL GENE-EXPRESSION PATTERN

FUNCTION OF VIRALLY INDUCED CELLULAR TRANSCRIPTS

ACKNOWLEDGMENTS

REFERENCES

2 Chipping Away at HIV Pathogenesis

THE NEW AND IMPROVED GENETIC CODE

GENECHIP TECHNOLOGY IN GENOMICS RESEARCH

OVERVIEW OF HIV PATHOGENESIS

BIOINFORMATIC ANALYSIS OF HIV EFFECTS

FUTURE OF GENOMICS

REFERENCES

3 Microarray Analysis of Human Papillomavirus Pathogenesis

OVERVIEW

PATHOGENESIS OF HPV

APPLICATION OF MICROARRAY TECHNOLOGY IN UNDERSTANDING HPV PATHOGENESIS

REFERENCES

4 Ribozymes as Gene Therapeutic Agents for HIV/AIDS

INTRODUCTION

HIV PATHOGENESIS AND ANTI-RETROVIRAL THERAPY

RIBOZYME DESIGN AND IN VITRO EFFICACY

IN VIVO EFFICACY-ANIMAL MODELS

GENE-THERAPY CLINICAL TRIALS

DRUG RESISTANCE AND GENE THERAPY

HIV GENE THERAPY IN THE CLINIC

SUMMARY— FROM SEQUENCE TO PRODUCT

REFERENCES

II Bacteria

5 Genomics and New Technologies Applied to Antibacterial Drug Discovery

INTRODUCTION

UPDATE ON GENOMIC SEQUENCE AND ANALYSIS RESOURCES AVAILABLE

COMPARATIVE GENOMICS

EVALUATING TARGET ESSENTIALITY

POTENTIAL NEW TARGETS FROM GENOMIC APPROACHES

GENOMIC APPROACHES TO DISCOVERY OF FUNCTION— FUNCTIONAL GENOMICS

ASSAYS/SCREENS FOR TARGETS OF UNKNOWN OR INTRACTABLE FUNCTION

CONSIDERATION OF NONESSENTIAL TARGETS

FUTURE DIRECTIONS/CHALLENGES FOR GENOMICS

ACKNOWLEDGMENT

REFERENCES

6 Genomics of the Mycobacterium tuberculosis Complex and BCG Vaccines

BACKGROUND

INFORMATION FROM COMPLETE GENOME SEQUENCING

GENOMIC VARIABILITY BETWEEN SUBSPECIES OF THE M. tuberculosis COMPLEX

GENOMIC ANALYSIS OF M. bovis BCG VACCINES

SUMMARY

REFERENCES

7 Bacterial “Genes-to-Screens” in the Post-Genomic Era

INTRODUCTION

BACTERIAL GENOMIC INFORMATION: A SUMMARY

GENOMICS AND MICROBIAL PHYSIOLOGY

TARGET IDENTIFICATION

SCREENING FOR NEW INHIBITORS

CHALLENGES AND SUMMARY

REFERENCES

8 DNA Microarray Expression Analysis in Antibacterial Drug Discovery

INTRODUCTION

BACTERIAL DNA MICROARRAY TECHNOLOGIES

BACTERIAL MICROARRAY EXPRESSION ANALYSIS AND DRUG TARGET SELECTION

BACTERIAL TRANSCRIPTIONAL RESPONSES TO ANTIMICROBIALS

CONCLUSIONS AND FUTURE DIRECTIONS

REFERENCES

9 The Influence of Genomics on the Molecular Epidemiology of Nosocomial Pathogens

INTRODUCTION

DEFINING EPIDEMIOLOGICAL INTERRELATIONSHIPS

EPIDEMIOLOGICAL ANALYSIS: MOVING FROM PHENOTYPE TO GENOTYPE

BEYOND PFGE AND PCR: SEQUENCE-BASED MOLECULAR EPIDEMIOLOGY

CURRENT APPROACHES TO SEQUENCE-BASED EPIDEMIOLOGICAL ANALYSIS

THE FUTURE OF SEQUENCE-BASED TYPING IN THE AGE OF GENOMICS

CONCLUSION: MOLECULAR EPIDEMIOLOGYAND GENOMICS

REFERENCES

10 Borrelia Genomics as a Tool for Studying Pathogenesis and Vaccine Development

INTRODUCTION

BRIEF HISTORY OF BORRELIA

GENERAL CLINICAL SIGNS

CHARACTERISTICS OF THE GENUS BORRELIA

HOST-PARASITE INTERACTIONS

ANIMAL MODELS OF BORRELIA INFECTION

VACCINE DEVELOPMENT AGAINST BORRELIA SPIROCHETES

FUTURE VACCINE STRATEGIES

ACKNOWLEDGMENT

REFERENCES

III Fungi

11 Antifungal Target Discovery and Evaluation

INTRODUCTION

ANTIFUNGAL DRUG DISCOVERY

S. cerevisiae: A MODEL FOR FUNGAL PATHOGENS

IN VIVO TARGET VALIDATION

VIRULENCE FACTORS

DRUG DISCOVERY ON A GENOMIC SCALE

CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

12 Antifungal Drug Discovery: Old Drugs, New Tools

MYCOSES

ANTIFUNGAL DRUG THERAPIES

IN SEARCH OF NEW ANTIFUNGAL DRUGS

GENOMICS-BASED ANTIFUNGAL DRUG DISCOVERY

CONCLUDING REMARKS

REFERENCES

13 Cryptococcus neoformans

INTRODUCTION

C. neoformans AS A MODEL SYSTEM FOR GENOME-WIDE FUNCTIONAL GENOMICS AND PROTEOMIC ANALYSIS OF PATHOGENESIS AND DEVELOPMENT OF ANTIFUNGAL THERAPIES

THE FUTURE OF DRUG DISCOVERY AND PATHOGENESIS STUDIES IN C. neoformans

CONCLUSION

REFERENCES

14 Antifungal Target Selection in Aspergillus nidulans

INTRODUCTION

ANTIFUNGAL TARGETS, DRUGS, AND RESISTANCE

THE GENOMICS APPROACH

ESSENTIAL GENES AS POTENTIAL TARGETS

ACKNOWLEDGMENTS

REFERENCES

15 Functional Genomics of Histoplasma capsulatum

INTRODUCTION

PHYSIOLOGY OF DIMORPHISM

THE GENOME OF HISTOPLASMA

MOLECULAR BIOLOGY OF DIMORPHISM

VIRULENCE DETERMINANTS

THE FUTURE

ACKNOWLEDGMENTS

REFERENCES

16 Gene-Finding in Coccidioides immitis

INTRODUCTION

GEOGRAPHIC DISTRIBUTION

MOLOGYYC

SPHERULE GROWTH AND SEGMENTATION

TAXONOMIC AFFINITY OF C. immitis

GENOME STRUCTURE OF C. immitis

GENE-FINDING IN C. immitis

REFERENCES

IV Protozoa

17 Toxoplasma gondii

INTRODUCTION: EVOLUTIONARY GENOMICS OF Toxoplasma gondii

CHEMOTHERAPEUTIC TARGETS IN THE MITOCHONDRION

CHEMOTHERAPEUTIC TARGETS IN THE APICOPLAST

COMPUTATIONAL APPROACHES TO THE IDENTIFICATION OF CHEMOTHERAPEUTIC TARGETS

CONCLUSION

ACKNOWLEDGMENTS

REFERENCE

18 The Molecular Biology and Pathogenicity of Entamoeba histolytica

INTRODUCTION

EPIDEMIOLOGY

CLINICAL MANIFESTATIONS OF AMEBIASIS

LIFE CYCLE OF E. histolytica

THE GENOME

GENOMIC-SEQUENCING STRATEGY

PATHOGENICITY OF E. histolytica

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