(Ebook) Our Human Variability : A Conversation with Stephen Scherer by Howard Burton ISBN 9781771700535, 177170053X

(Ebook) Our Human Variability : A Conversation with Stephen Scherer by Howard Burton ISBN 9781771700535, 177170053X

This book is based on an in-depth conversation with Stephen Scherer, the GlaxoSmithKline Research Chair in Genome Sciences at the Hospital for Sick Children and University of Toronto. Stephen Scherer discusses his lifelong passion for science that culminated in his groundbreaking discovery of copy-number variation. Further topics include a detailed exploration of his work in autism research and how copy number variation brings us a deeper understanding of both human variability and disease.This carefully-edited book includes a detailed introduction, questions for discussion at the end of each chapter and connections with other books in the Ideas Roadshow Conversations series.CHAPTERS:I. James Watson's Legacy - From The Double Helix to NRC to chromosome 7II. In the Lab - The first hints of copy number variationIII. Chromosome 7 - Mapping genetic markers to chromosomesIV. Back to Basics - Nucleotides, DNA, chromosomes, genes and mutationsV. Revolutionary Stirrings - Detecting copy number variationVI. Going Global - Large-scale variation for allVII. Variability and Evolution - Appreciating biological variabilityVIII. Causes and Implications - Complexity galore: autism and other conditionsIX. Towards Treatment - Early diagnoses and equilibrium-restoring medicinesX. The Definition of Diseases - More complicated that you might thinkXI. Probing Deeper - Stem cells, pleiotropy and environmental factorsXII. Ethical and Societal Issues - Towards responsible progressXIII. Future Possibilities - Potentially unravelling biological complexityXIV. Contact with Autism - Serendipitous occurrencesXV. Nobel Thoughts - The perks and perils of prizesXVI. The Human Condition - Genetic windows on humanityABOUT IDEAS ROADSHOW CONVERSATIONS:Ideas Roadshow Conversations present a wealth of candid insights from leading experts through a focused yet informal setting. Presented in an engaging conversational format, these books not only explore cutting-edge academic research, but also reveal the inspirations and personal journeys behind the research. They are explicitly designed to provide a unique window into frontline research and scholarship that wouldn't otherwise be experienced through standard lectures and textbooks. Howard Burton holds a PhD in theoretical physics and an MA in philosophy and was the Founding Director of Canada's Perimeter Institute for Theoretical Physics.