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Available4.7
18 reviews
ISBN 10: 084933229X
ISBN 13: 9780849332296
Author: Sang Woon Choi, Simonetta Friso
The complete mapping of the human genome, along with the development of sophisticated molecular technologies, has accelerated research on the relationship between nutrients and genes. This has led to compelling evidence garnered from epidemiological and experimental observations supporting the idea that the interaction between nutrients and genes is one of the most important mechanisms influencing carcinogenesis.
Nutrient-Gene Interactions in Cancer brings together leading authorities in the field who provide an overview and look specifically at the mechanisms known to underlie each nutrient and gene interaction. The book examines the multi-functional relationship linking nutrition and cancer development, including the complex role nutrients have in modulating cancer growth via interactions with specific genes, and the emerging new strategy for cancer chemoprevention that is based on a deepened understanding of this relationship. The authors also provide freshly illuminating information on many well-known interactions.
The first part of the book includes chapters on the basic elements of biology and pathobiology of gene-nutrient interactions with a focus on mechanisms and biomarkers. This is followed by chapters, which detail specific gene-nutrient interactions, offering numerous examples supported by recent investigations. The final chapter looks to the future, considering the potential for further investigation by outlining new perspectives in this rapidly growing area of medical science.
While this work is especially valuable to science investigators, it will also be of great interest to clinicians who manage cancer patients, in that it presents useful tools that advance the clinical value of gene-nutrient interaction research in medical nutrition and oncology.
Chapter 1 Nutrient and Gene Interactions in Cancer
Chapter 2 Candidate Mechanisms for Interactions between Nutrients and Genes
Chapter 3 Biomarkers for Nutrient–Gene Interactions
Chapter 4 Interaction between Folate and Methylene-tetrahydrofolate Reductase Gene in Cancer
Chapter 5 Genetic Variability in Folate-Mediated One-Carbon Metabolism and Cancer Risk
Chapter 6 S-Adenosylmethionine and Methionine Adenosyltransferase Genes
Chapter 7 Effects of Carotenoid Supplementation on Signal Transduction Pathways: Significance in Lung Cancer Prevention
Chapter 8 The Actions of the Vitamin D Receptor in Health and Malignancy; Polymorphic Associations and Gene Regulatory Actions
Chapter 9 The Role of Alcohol Dehydrogenase Polymorphism in Alcohol-Associated Carcinogenesis
Chapter 10 Genetic Polymorphism of N-Acetyltransferase Genes as Risk Modifiers of Colorectal Cancer from Consumption of Well-Done Meat
Chapter 11 Ferritin and Serine Hydroxymethyltransferase
Chapter 12 Brassica–Gene Interactions and Cancer Risk
Chapter 13 Conclusions and Future Perspectives
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Tags: Sang Woon Choi, Simonetta Friso, Nutrient Gene, Cancer
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