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Noninvasive reduction of neural rigidity alters autistic behaviors in humans by Takamitsu Watanabe & Hidenori Yamasue instant download

  • SKU: EBN-239922814
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Instant download (eBook) Noninvasive reduction of neural rigidity alters autistic behaviors in humans after payment.
Authors:Takamitsu Watanabe & Hidenori Yamasue
Pages:updating ...
Year:2025
Publisher:x
Language:english
File Size:3.46 MB
Format:pdf
Categories: Ebooks

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Noninvasive reduction of neural rigidity alters autistic behaviors in humans by Takamitsu Watanabe & Hidenori Yamasue instant download

Nature Neuroscience, doi:10.1038/s41593-025-01961-y

Autistic behaviors correlate with reductions in specifc brain-state Check for updatestransitions in global neural dynamics, implying that the mitigation of such rigid brain dynamics may alter autistic traits. To examine this possibility, we investigated longitudinal behavioral efects of state-dependent transcranial magnetic stimulation (TMS) in autistic adults. We found that excitatory TMS over the right parietal lobule decreased neural rigidity, which commensurately reduced social and nonsocial autistic behaviors. Specifcally, TMS-induced neural fexibility immediately decreased cognitive infexibility and slowly reduced overstable perception and atypical nonverbal communication. In particular, perceptual overstability was reduced after TMS-induced neural fexibility strengthened the coupling between the frontoparietal and visual networks, whereas atypical nonverbal communication became less explicit when the neural fexibility enhanced the coupling between the frontoparietal, default mode and salience networks. These results indicate that alteration of neural rigidity could change multiple autistic traits.

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