(Ebook) New Strategies in Stroke Intervention Ionic Transporters Pumps and New Channels 1st Edition by Thiruma V Arumugam, Eitan Okun, Mark P Mattson, Lucio Annunziato ISBN 1607612798 9781607612797

(Ebook) New Strategies in Stroke Intervention Ionic Transporters Pumps and New Channels 1st Edition by Thiruma V Arumugam, Eitan Okun, Mark P Mattson, Lucio Annunziato ISBN 1607612798 9781607612797

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ISBN 10: 1607612798 
ISBN 13: 9781607612797
Author: Thiruma V Arumugam, Eitan Okun, Mark P Mattson, Lucio Annunziato

Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized. Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for curing stroke is far less understood than for many other normal and pathological conditions. New Strategies in Stroke Intervention: Ionic Channels, Pumps, and Transporters, analyzes the roles played by targets in stroke development and the potential action of drugs modulating these proteins. This book provides a groundbreaking review of these ionic channels, pumps, and transporters as regulators of neuronal ionic homeostasis, providing a better understanding of ischemic brain disorders and the new pharmacological avenues for a cure.

(Ebook) New Strategies in Stroke Intervention Ionic Transporters Pumps and New Channels 1st Table of contents:

1. Basis of Ionic Dysregulation in Cerebral Ischemia
2. Why have Ionotropic and Metabotropic Glutamate Antagonists Failed in Stroke Therapy?
3. Mitochondrial Channels as Potential Targets for Pharmacological Strategies in Brain Ischemia
4. Endoplasmic Reticulum Calcium Homeostasis and Neuronal Pathophysiology of Stroke
5. The Na + /Ca 2+ Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia
6. The “Loop” Diuretic Drug Bumetanide-Sensitive Na + -K + -Cl - Cotransporter in Cerebral Ischemia
7. The Na + /H + Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia
8. The Na + /K + -ATPase as a Drug Target for Ischemic Stroke
9. Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment
10. Role of TRPM7 in Ischemic CNS Injury
11. Subtypes of Voltage-Gated Ca 2+ Channels and Ischemic Brain Injury
12. The Diverse Roles of K + Channels in Brain Ischemia
13. Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke

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Tags: Thiruma V Arumugam, Eitan Okun, Mark P Mattson, Lucio Annunziato, Strategies, Intervention