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Status:
Available4.6
31 reviews
ISBN 10: 1420019546
ISBN 13: 9780849336102
Author: Akira Sawa, Melvin G McIinnis
1 Alzheimer’s Disease: A Complex Paradigm
INTRODUCTION
GENETICS OF EARLY ONSET ALZHEIMER’S DISEASE: FINDING GENES
The Amyloid Precursor Protein Gene
The Presenilins
GENETICS OF LATE ONSET ALZHEIMER’S DISEASE: THE COMPLEX DISEASE CHALLENGE
Genome-Wide Linkage Scans for Late Onset Alzheimer’s Disease
Using Other Phenotypes and Covariates in Late Onset Alzheimer’s Disease Linkage Analysis
ASSOCIATION STUDIES
THE MITOCHONDRIAL HYPOTHESIS
REFERENCES
2 Gene-Mapping Studies for Schizophrenia: How Useful Are They for the Clinician?
INTRODUCTION
BACKGROUND TO GENE-MAPPING STUDIES
UPDATE ON GENE-MAPPING EFFORTS
Linkage Studies
Association Studies
A Critical Appraisal of Genetic Association Studies
Neuregulin 1
Dysbindin or Dystrobrevin-Binding Protein
Regulator of G-Protein Signaling
Disrupted in Schizophrenia 1
G72 and D-Amino Acid Oxidase
Catechol O-Methyl Transferase
Dopamine Receptor, Subtype 3
MAPPING GENES FOR TRAITS THAT USEFULLY COMPLEMENT THE CONVENTIONAL DIAGNOSTIC PHENOTYPE
CONCLUSIONS AND PROSPECTS FOR THE FUTURE
REFERENCES
3 Rare Genes of Major Effect in Neuropsychiatric Diseases
INTRODUCTION TO COMPLEX NEUROPSYCHIATRIC DISORDERS
CHROMOSOMAL ABNORMALITIES: BALANCED AND UNBALANCED FORMS
PHENOTYPES ASSOCIATED WITH TRANSLOCATION EVENTS
CAVEATS FOR CYTOGENETICS RESEARCH
COMPLEX PHENOTYPES RESULTING FROM TRANSLOCATIONS: A PARADOX OR AN INSIGHT?
TESTING CANDIDATE GENE ALLELES IN THE POPULATION: AN UNHELPFUL DOGMA?
TOWARD A MECHANISTIC UNDERSTANDING OF NEUROPSYCHIATRIC DISORDERS?
The Primary Disrupted in Schizophrenia Mutation and Association with Disease in the Population
Protein Interaction Studies Suggest Disrupted in Schizophrenia Functions as a Hub for the Assembly of Distinct Protein Complexes
Emerging Pathways and Biology
SUMMARY
ACKNOWLEDGMENT
REFERENCES
4 Neurotransmission
INTRODUCTION
GLUTAMATERGIC NEUROTRANSMISSION
Glutamate
D-Serine
G72, D-Amino Acid Oxidase, and Serine Racemase
Potential Therapeutic Approach
CHOLINERGIC NEUROTRANSMISSION
Acetylcholine
a7 Nicotinic Acetylcholine Receptors
a7 Nicotinic Acetylcholine Receptors and Auditory Sensory Gating P50
Animal Models of Auditory Sensory Gating
CROSS-TALK BETWEEN GLUTAMATERGIC AND CHOLINERGIC NEUROTRANSMISSIONS
Kynurenic Acid
CONCLUDING REMARKS
REFERENCES
5 Molecular Genetic Study of Schizophrenia Based on Neurodevelopmental Hypothesis
INTRODUCTION
MOLECULAR MECHANISIMS OF NEURODEVELOPMENT
Neuronal Migration
Neuronal Polarization and Axon Elongation
Dendrite Formation
Synapse Formation and Maturation
GENETIC STUDIES OF SCHIZOPHRENIA BASED ON NEURODEVELOPMENTAL HYPOTHESIS
Dystrobrebin-Binding Protein 1 (Located on 6p22.3)
Neuregulin 1 (Located on 8p22-p11)
AKT1 (Located on 14q32.32)
Disrupted in Schizophrenia 1 (Located on 1q42.1) [L19]
Reelin (Located on 7q22)
FUTURE DIRECTIONS: SELECTION OF PHENOTYPE FOR NEURODEVELOPMENTAL HYPOTHESIS
REFERENCES
6 Model Organisms and Neurogenetics
WHAT ARE APPROPRIATE TRANSGENIC MODELS OF PSYCHIATRIC ILLNESS?
DEVELOPING TRANSGENIC MODELS BASED ON HUMAN GENETICS STUDIES
ALZHEIMER’S DISEASE
PARKINSON’S DISEASE
TRINUCLEOTIDE REPEAT EXPANSIONS
BIPOLAR DISORDER, DEPRESSION, ANXIETY DISORDERS, AND ATTENTION DEFICIT DISORDER
AUTISM AND RETT’S SYNDROME
SCHIZOPHRENIA
SUMMARY AND PERSPECTIVES
ACKNOWLEDGMENTS
REFERENCES
7 Toward a Unified Model of Neurogenetics
INTRODUCTION
GENETIC FACTORS IN SCHIZOPHRENIA
Role of Disrupted in Schizophrenia 1 in Neurodevelopment
Role of Disrupted in Schizophrenia 1 in Neurotransmission
ENVIRONMENTAL FACTORS IN SCHIZOPHRENIA
Stress
Immune Response (Cytokine Release)
Viral Infection
ANIMAL MODELS TO STUDY GENE–ENVIRONMENT INTERACTIONS
REFERENCES
8 Clinical Endophenotypes: Implications for Genetic and Clinical Research
INTRODUCTION
PHENOTYPES AND ENDOPHENOTYPES
ALTERNATIVE CLINICAL PHENOTYPES
NEUROCOGNITIVE ENDOPHENOTYPES
NEUROIMAGING ENDOPHENOTYPES
BEHAVIORAL ENDOPHENOTYPES
SUMMARY/FUTURE DIRECTIONS
REFERENCES
9 Pharmacogenetics and Pharmacogenomics in Psychiatry: Clinical Applications
INTRODUCTION
THE HERITABILITY OF DRUG RESPONSE
INVESTIGATING GENETIC INFLUENCE ON TREATMENT RESPONSE
WHAT HAS PHARMACOGENETICS DONE FOR US?
PHARMACOGENETIC FINDINGS
Pharmacokinetic Investigation
CYP Enzymes: Determinants of Metabolic Rate
Pharmacodynamic Investigations
Genetic Variation in Neurotransmitter Systems: Influence on Clinical Outcome
NON-GENETIC FACTORS
CLINICAL APPLICATIONS: CURRENT AND FUTURE
Adjustment of Therapeutic Dose
Prediction of Treatment Response: Are We There Yet?
Prediction of Antipsychotic Response
Prediction of Response to Antidepressants
Other Psychotropic Treatments
Propensity to Develop Side Effects to Antipsychotics
PHARMACOGENOMICS: THE FUTURE IS HERE
Clinical Trials: Finding Genetic Determinants at Early Stages of Drug Development
CONCLUSIONS
REFERENCES
10 Translational Research in Psychiatric Diseases
TRANSLATIONAL RESEARCH: WHAT IS IT ANYWAY?
WHAT IS THE DOMAIN OF TRANSLATIONAL RESEARCH?
TRANSLATIONAL RESEARCH: A NEW FOCUS, AN EMERGING FIELD
TRANSLATIONAL PERSPECTIVES
The Genotype and Genomic Sequence
Physiology, Biochemistry, and Psychiatric Genetics
Stress and Inflammatory Mediators
Catechol-O-Methyltransferase
Expression Profiling
Neuropsychology, Environment, and Disease Phenotypes
PLEA FOR DIMENSIONS IN PSYCHIATRY: CAN THEY EXIST WITHIN DIAGNOSTIC CATEGORIES?
THE PROMISE OF TRANSLATIONAL RESEARCH
neurogenetics disorders
psychiatric genetics and the structure of psychopathology
psychiatric genetic disorders
psychiatry neurogenetics
psychiatric neuroscience
Tags: Akira Sawa, Melvin G McIinnis, Neurogenetics, psychiatric disorders
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