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ISBN 10: 0521780705
ISBN 13: 9780521780704
Author: Pedro A de Alarcon, Eric J Werner, J Lawrence Naiman
Written by practising physicians specializing in pediatric hematology, neonatology, immunology, pediatric infectious disease and transfusion medicine, this is a practical guide to the pathogenesis, recognition and management of hematologic problems in the neonate. The focus is on clinical issues encountered by pediatric specialists, and there are chapters devoted to disorders of leukocytes, platelets, procoagulant and anticoagulant proteins, and disorders of red blood cells. Neonatal transfusion, malignant disorders in the newborn, neonatal hemoglobinopathy screening, harvesting and storage of umbilical cord stem cells are also covered, and practical approaches to diagnosis and treatment given.
1 Neonatal hematology: a historical overview
Erythroblastosis fetalis
Hemorrhagic disease of the newborn
Epilog
References
2 Disorders of the fetomaternal unit
Hemorrhagic disorders of the fetoplacental unit
Abruptio placenta and placenta previa
Fetomaternal bleeds
Diagnosis
Management
Twin ?twin transfusion syndrome
Clinical manifestations
Management
Hematologic consequences to the fetus of maternal diseases
Diabetes
Hypertension
Maternal malignancy
Autoimmune syndromes
Hematologic effects of maternal medications/toxins
Smoking
Maternal medications
Maternal nutritional deficiencies
Iron
Folate
Cobalamin
Intrauterine infection
Toxoplasmosis
Syphilis
Congenital viral infections
Summary
References
3 Erythropoiesis, red cells, and the approach to anemia
Neonatal erythropoiesis
The erythrocyte
Hemoglobin
Erythrocyte cell membrane
Biochemistry of the red cell
Postnatal changes in oxygen delivery
Differential diagnosis of anemia in the newborn
Introduction
Initial assessment
Blood loss
Hemolysis
Failure of production
Therapy
Algorithm
References
4 Anemia of prematurity indications for erythropoietin therapy
Introduction
Physiology of anemia of prematurity
Therapy for anemia of prematurity
Minimizing blood loss
Erythrocyte transfusions
rhEPO therapy for anemia of prematurity
Summary of rhEPO in Prematurity 2004
Iron status of premature infants
Perinatal iron acquisition
Measuring iron status in premature infants
Postnatal iron sources
Enteral iron supplementation
Parenteral iron supplementation
Long-term iron status of premature infants
Conclusion
References
neonatal hematology
neonatal books
textbook of neonatal resuscitation 8th edition pdf free
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Tags: Pedro A de Alarcon, Eric J Werner, J Lawrence Naiman, Neonatal, Hematology
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