(Ebook) Nano Biomedical Engineering 2012 1st edition by Takami Yamaguchi 1848169051 9781848169050

(Ebook) Nano Biomedical Engineering 2012 1st edition by Takami Yamaguchi 1848169051 9781848169050

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ISBN-10 :  1848169051 

ISBN-13 : 9781848169050

Author: Takami Yamaguchi 

This book focuses on nano-biomedical engineering, the most important key technology in the world in the 21st century. It covers virtually everything within current and future research and the development of biomedical engineering. It follows four groups within the field, namely nano-biomechanics, nano-bioimaging, nano-biodevices, and nano-biointervention.

Nano-Biomedical Engineering 2012 1st Table of contents:

1. Introduction
2. Theoretical Analysis of Destabilization Phenomenon
2.1. Destabilization Mechanism
2.2. Stabilized MI Simulation Scheme
3. Confirmation of Theoretical Results by Numerical Examples
4. Conclusions
Acknowledgments
References
Challenges in Research on Auditory Mechanics Michio Murakoshi, Shun Kumano, Kenji Ishihara, Koji Iid
1. Inner Ear Protection from Acoustic Trauma by Heat Stress
2. Prestin, the Inner Ear Motor Protein
2.1. Structure of Prestin
2.2. Function of Prestin
2.2.1. GTSRH sequence
2.2.2. Mutation-induced reinforcement
3. Restoration of Transport Function and Anion Exchanger Activity of Missense Pendrin Mutations
Acknowledgments
References
Skeletal Muscle and Health Ryoichi Nagatomi
1. Introduction
1.1. Motor Function and Health in Population Studies (Fig.1)
1.2. Advanced Glycation End Product and Skeletal Muscle Function (Fig.1)
1.3. Sophisticated Cellular Regulation of Skeletal Muscle Damage-repair Process
2. Conclusions
Acknowledgments
References
Dynamic Imaging of Cross-Sectional Deformation of Endothelial Cells During Exposure to Fluid Shear S
1. Introduction
2. Materials and Methods
2.1. Cell Culture and Fluorescent Labeling
2.2. Experimental Setup and Procedure
2.3. Image Correlation
2.4. Finite Element Method (FEM) Analysis
2.5. Calculation of Shear Modulus
3. Results and Discussion
3.1. FSS-induced Deformation of ECs
3.2. Shear Modulus of HUVECs
3.3. Role of Actin Filaments in FSS-induced Deformation
4. Conclusion
Acknowledgments
References
Computational Biomechanics of Blood   Flow at Macro- and Micro-Scales Takami Yamaguchi, Takuji Ishikaw

1. Introduction
2. A Hemodynamic Index for the Initiation of a Cerebral Aneurysm
2.1. Methods
2.2. Results and Discussion
3. Modeling of Blood Flow in Malaria Infection
3.1. Methods
3.2. Results and Discussion
4. Conclusions
References
Gradient Diffusion of Red Blood Cells Flowing in a Straight Microchannel Cheng-Hsi Chuang Takuji Ish
1. Introduction
2. Methods
2.1. Working Fluids and a Microchannel
2.2. Experimental Setup and Procedures
2.3. Analysis of Dispersion Front and Gradient Dispersion Coefficient
3. Results and Discussions
4. Conclusions
Acknowledgments
References
Entrapment of Fresh Water Ciliates at the Interface Fluid-Air Jonathan Ferracci,Takuji Ishikawa, Hir
1. Introduction
2. Method
3. Results
3.1. Control: Cell Behaviour Inside the Medium
3.2. Characterization of Cells’ Behaviour at the Interface
3.3. Effect of Chemotaxis and Gravitaxis
3.4. Effect of Surfactant
4. Conclusion
Acknowledgments
References
Involvement of Intercellular Junction Proteins in the Redistribution of Focal Adhesions and Orientat
1. Introduction
2. Methods
2.1. Cyclic Stretch Experiment
2.2. Image Analysis
3. Results
4. Discussion
5. Conclusion
Acknowledgments
References
Eigenvalue Analysis for Error Dynamics of Ultrasonic-Measurement- Integrated Simulation of Blood Flo
1. Introduction
2. Eigenvalue Analysis
3. Numerical Experiment
4. Conclusion
Acknowledgments
References
Distribution of Traction Force in Smooth Muscle in Response to Myosin Light Chain Phosphorylation Ka
1. Introduction
2. Materials and Methods
2.1. Cell Culture
2.2. Traction Force Measurement Using a Micropillar Device
2.3. Treatment with Y-27632 and Calyculin A
2.4. Western Blot
3. Results
4. Discussion
5. Conclusions
Acknowledgments
References
Comprehensive and Integrative Exploration of Homeostatic Systems Tomiaki T.Kawaoka, Sho Onodera, Shi
1. Overview of Research History
1.1. Enhancement of Sports Ability
1.1.1. The bodies in athletes
1.1.2. Plyometric Training
1.1.3. Experimental investigation and summary of the effects of various techniques on sports ability
1.2. Physical Conditioning
1.2.1. A survey of physical state in related to sports injuries
1.2.2. Case study on the improvement of physical state
1.3. Delayed-Onset Muscle Soreness and Eccentric Exercise-Induced Muscle Damage
1.3.1. A questionnaire for junior high school students
1.3.2. Literature study
1.4. Regeneration of Damaged Skeletal Muscle
2. Future Directions
2.1. Revealing The Regulation of Homeostatic Systems
2.2. Practical Applications
Acknowledgments
References
Transfer Function of Tube-Shaped Poly (Vinyl Alcohol) Hydrogel Blood Vessel Biomodel Hiroyuki Kosuke
1. Introduction
2. Methods
2.1. Materials
2.2. Preparation of Tube-shaped Poly (vinyl alcohol) Hydrogel
2.3. Measurement of Transfer Function
3. Results and Discussion
4. Conclusion
References
Fundamental Study on Poly (Vinyl Alcohol) Hydro Gel Vessel Model with Anisotropic And Non-Linear Mec
1. Introduction
2. Method
2.1. PVA-H Vessel Model
2.2. Experiment
3. Result
4. Discussion
5. Conclusions
Acknowledgments
References
Micro-Viscoelastic Measurement of Fluorescently Labeled Actin Bundles Isolated from Smooth Muscle Ce
1. Introduction
2. Materials and Methods
2.1. Tensile Test System
2.2. Preparation of Actin Bundle
3. Results and Discussion
4. Conclusion
Acknowledgments
References
Behavior of A Spherical Capsule in Simple Shear flow near an Infinite Plane Stephanie Nix,Yohsuke Im
1. Introduction
2. Method
3. Results and Discussion
4. Conclusions
References
Combination of Cyclic Stretch and Hypoxia Increases Macrophage Production of Matrix Metalloproteinas
1. Introduction
2. Material and Methods
2.1. Cell Culture
2.2. Cyclic Stretch Experiment
2.3. Gelatin Zymography
2.4. ELISA
2.5. Statistical Analysis
3. Results
3.1. Increased MMP-9 Production by Macrophages under Combined Cyclic Stretch and Hypoxia
3.2. Increased Macrophage Production of Inflammatory Cytokines and SMC Apoptosis Induced by Macropha
4. Discussion
Acknowledgments
References
Radial Dispersion of Tracer Particles through High-Hematocrit Blood Flow within a Capillary Tube Mar
1. Introduction
2. Materials and Methods
2.1. Experimental Setup
2.2. Working Fluids
2.3. Experimental Procedures
2.4. Radial Dispersion Coefficient
3. Results
3.1. Spreading of Tracer Particles in 10% Hct Blood
3.2. Effect of Hct on the Dispersion Coefficient
4. Conclusions
Acknowledgments
References
Analysis and Techniques for Controlling Kinesin-Driven Microtubules in Nanoscale Transport Systems S
1. Introduction
2. Analytical Results and Techniques
2.1. Fundamental Technique for Observation of Gliding MTs
2.2. Effects of MT Length and Kinesin Density on MT Motility
2.3. Size-Sorting of MTs with Microgrooves
2.4. Semi-automated Tip-Tracking for Gliding MTs
3. Toward Developing Nanoscale Transport System
Acknowledgments
References
Force Transmission via Stress Fibers in Endothelial Cells exposed to Fluid Shear Stress Yosuke Ueki,
1. Introduction
2. Materials and Methods
2.1. Cell Culture and Transfection
2.2. Experimental Setup and Procedure
3. Results
4. Discussion
5. Conclusion
Acknowledgments
References
Study on Ultrasonic-Measurement-Integrated Simulation for Complex Blood Flows Flow Rate Estimation T
1. Introduction
2. Ultrasonic-measurement-integrated Simulation System
3. Flow Rate Estimation Method
4. Results and Discussion
5. Conclusions
Acknowledgments
References
Experimental Hemodynamic Study with Several Stents in Cerebral Aneurysm model using PIV Chang-Ho Yu,
1. Introduction
2. Materials and Methods
2.1. Configurations of the Stents and Cerebral Silicone Aneurysm Model
2.2. Particle Image Velocimetry (PIV)
3. Results and Discussion
3.1. Effectiveness of the Stent Porosity
3.2. Flow Patterns and Vortices
4. Conclusion
Acknowledgments
References
Nano-Bioimaging
Development and aging of The Human Brain Studied with Brain Magnetic Resonance Image Hiroshi Fukuda,
1. Introduction
2. General Methods
2.1. MRI Data Acquisition
2.2. Image Processing and Image Analyses
3. Results of the Three Themes
3.1. Correlation Between Gray Matter Density-adjusted Brain Perfusion and Age Using Brain MR Images
3.1.1. Introduction
3.1.2. Method
3.1.3. Results
3.1.4. Discussion and conclusion
3.2. Computation of Standard Brain Model for Each Age and Sex Group Using Anatomical Standardization
3.2.1. Introduction
3.2.2. Method
3.2.3. Results
3.2.4. Discussion and conclusion
3.3. Analysis of Structural Brain Network Based on Graph Theory
3.3.1. Introduction
3.3.2. Method
3.3.3. Results
3.3.4. Discussion and conclusion
Acknowledgments
References
High Frame Rate Ultrasonic Imaging of Arteries for Detailed Analyses of Dynamics Hideyuki Hasegawa a
1. Introduction
2. Principles
2.1. Parallel Beamforming
2.2. Estimation of Two-dimensional Motion of the Arterial Wall
2.3. Directional Flow Estimation Using Gradient-Based Optical Flow
3. Basic Experimental Results
3.1. Comparison of Spatial Resolutions of Conventional Linear Scanning and Parallel Beamforming
3.2. Measurements of the Cylindrical Phantom for Evaluation of Accuracy in Strain Estimation
4. In Vivo Experimental Results
4.1. Simultaneous Imaging of Artery-Wall Radial Strain and Blood Flow
4.2. Estimation of 2D Motion of Arterial Wall
4.3. Directional Flow Velocity Estimation
4.4. Measurement of Pulse Wave Velocity
5. Conclusions
References
High Resolution and Functional Biomedical, Imaging for Cancer Diagnosis Yoshifumi Saijo
1. Introduction
2. Ultrasound Speed Microscope for Prostatic Cancer
2.1. Objectives
2.2. Methods
2.2.1. Instrumental setup
2.2.2. Signal analysis
2.2.3. Prostate tissues
2.3. Results
2.4. Discussion
2.5. Summary
3. Development of Color-dependent Photoacoustic Imaging
3.1. Objectives
3.2. Methods
3.3. Results
3.3.1. Photoacoustic signal from gelatins
3.3.2. Color dependence of photoacoustic signal
3.4. Summary
4. Conclusions
Acknowledgments
References
Clinical Application of Multidetector-Row Computed Tomography to Evaluate Fine Vascular Structures K
1. Introduction
2. Method of Visualizing Fine Vascular Structures
2.1. Visualization of the Adrenal Vein by MDCT
2.1.1. CT examination
2.1.2. Adrenal venous catheters
2.2. Visualization of the Artery of Adamkiewicz
2.3. Visualization of the Proper Esophageal Artery Before Thoracoscopic Esophageal Surgery Using MDC
2.4. Preoperative Visualization of the Thoracic Duct Using MRI
3. Results
3.1. Result of Adrenal Vein Analyses.
3.1.1. MDCT visualization of RAV
3.2. Visualization of the Artery of Adamkiewicz
3.3. Visualization of the Esophageal Artery
3.4. Visualization of Thoracic Duct by MRI
4. Discussion
5. Discussion
References
The Promise of Nano-Bio-Imaging with Positron Emission Tomography and Radiopharmaceuticals Manabu Ta
1. Introduction
1.1. Nano-bio-imaging and Nuclear Medicine Technique
1.2. Information Available from the Living Human Brain
2. Nano-bio-imaging in Health Promotion Sciences
2.1. Neuroimaging in Exercise Physiology
2.2. Neuroimaging to Examine the Quality of Life (QOL) of Patients and Their Families
2.3. Neuroimaging of Autonomic Responses due to Alternative Therapies
3. Nano-bio-imaging in Clinical Pharmacology and Drug Development
3.1. Functional Imaging of the Histaminergic Nervous System
3.2. Functional Imaging while Car Driving and with Drug Side Effects
3.3. Nano-bio-imaging for Early Diagnosis of Cognitive Disorders
4. Conclusion
Acknowledgments
References
High-Intensity Focused Ultrasound Treatment Enhanced by Microbubbles Shin-Ichiro Umemura,Shin Yoshiz
1. Introduction
2. Theoretical Prediction of Enhancement of Ultrasonic Heating by Microbubbles [1]
3. Ultrasonic In Vivo Tissue Heating Enhanced by Encapsulated Microbubbles [1]
4. Enhancement of Ultrasonic Heating by Ultrasonically Generated Microbubbles [6]
5. Conclusions
References
Molecular Imaging of Sedative Properties Caused by Antihistamines Kazuhiko Yanai, Takeo Yoshikawa, S
1. Introduction and Background
1.1. Physiological Functions of the Histaminergic Neuron System
1.2. Pharmacological Features of Antihistamines
1.3. Sedative Properties of Antihistamines
2. Brain Histamine H1 Receptor Occupancy by Molecular Imaging
3. Future Perspectives
References
Development of Molecular Imaging Probe for in Vivo Imaging Misfolded Proteins Ryuichi Harada, Nobuyu
1. Introduction
2. Development of a-synuclein Binding Probe
3. Development of Optical Imaging Probe for Imaging A
4. Summary
Acknowledgments
References
[5-11C-Methoxy] Donepezil, A Pet Ligand for In-Vivo Visualization of Donepezil Binding to Acetylchol
1. Introduction
2. Materials and Methods
2.1. Kinetic Analysis of [11C]donepezil-PET
2.2. Clinical Study of PDD Using [11C]donepezil-PET
3. Results
3.1. Kinetic Analysis of [11C]donepezil-PET
3.2. Clincal Study of PDD Using [11C]donepezil-PET
4. Discussion
5. Conclusion
Acknowledgments
References
Use of Acoustic Nanoparticle for Imaging Tumour Angiogenesis Li Li, Tetsuya Kodama, Kei Takase and S
1. Introduction
2. Materials and Methods
2.1. Cells
2.2. In Vivo Experiments
2.3. Acoustic Nanoparticle Preparation
2.4. Scan Protocol for Contrast-enhanced Three-dimensional Imaging
2.5. Monitoring Tumour Angiogenesis by Nanoparticle-enhanced 3D High-frequency Ultrasound Imaging
2.6. Statistical Analysis
2.7. Results
3. Discussion
Acknowledgments
References
Measurement of Exercise-Induced Whole-Body Glucose Mtabolism using Quantitative and Semiquantative A
1. Introduction
2. Research Design
2.1. Subjects
2.2. Study Protocol
2.3. Quantitative Methods
2.4. Statistical Analysis
3. Results
4. Discussions and Conclusion
Acknowledgments
References
Development of High Spatial Resolution Pet Camera Specialized for Breast Cancer Diagnosis Masayasu M
1. Introduction
2. PEM Development and Applications
3. Development of the Prototype PEM Scanner
3.1. Large Area PEM Detector Unit
4. Prototype PEM Scanner
4.1. Gantry and Electronics Cabinet
4.2. Tube Phantom Scan
5. Commercial PEM Scanner
Acknowledgments
References
The Role of Histamine H3 Receptor in Pancreatic β-Cells Tadaho Nakamura, Takeo Yoshikawa, Naoya Nog
1. Introduction and Background
1.1. Histamine and Histamine Receptors
1.2. Histaminergic Effects on Obesity
1.3. G protein-coupled Receptors Expressed in Pancreatic Islets
2. The Expression and Function of Histamine Receptors in MIN6 Cells
2.1. Expression of Histamine Receptors
2.2. The Effect of R-(-)-alpha-methylhistamine, an H3R Agonist, on Glucose Induced Insulin Secretion
3. Discussion and Conclusion

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Tags: Nano Biomedical, Engineering, Takami Yamaguchi, biomedical engineering