Multiple infections with Omicron variants increase breadth and potency of Omicron-specific neutralizing antibodies by Lei You1,4, Luning Zhang1,4, Shengqun Ouyang1,4, Bo Gao1, Yanan i Yin1, Ziyang Xu1, Yao Chen1, Yiwen Zhu1, Shuangyan Zhang1, Zin Li 1, Jieming Qu 1,2,3✉, Bing Su 1✉ and Leng-Siew Yeap instant download

Multiple infections with Omicron variants increase breadth and potency of Omicron-specific neutralizing antibodies by Lei You1,4, Luning Zhang1,4, Shengqun Ouyang1,4, Bo Gao1, Yanan i Yin1, Ziyang Xu1, Yao Chen1, Yiwen Zhu1, Shuangyan Zhang1, Zin Li 1, Jieming Qu 1,2,3✉, Bing Su 1✉ and Leng-Siew Yeap instant download

Despite high vaccination rates, highly evolved Omicron variants have caused widespread infections and, in some cases, recurrentinfections in the human population. As the population continues to be threatened by new variants, it is critical to understand howthe dynamic cross-reactive antibody response evolves and affects protection. Here, we longitudinally profiled neutralizingantibodies in individuals who experienced three Omicron waves in China over an 18-month period following the lifting of theCOVID restriction. We found that individuals with BA.5/BF.7 and XBB dual infections had increased breadth and neutralizingpotency of Omicron-specific antibodies compared to those with a BA.5/BF.7 single infection, and were thus more resistant to JN.1/1234567890();,:XDV.1 infection in the third wave. During the second infection, a new imprint based on the previously infected variant wasestablished, and the antibodies developed high cross-reactivity against the Omicron variants and less against vaccine-derived WTSARS-CoV-2. Our results suggest that the high titer and breadth of cross-reactive antibodies from multiple infections may beprotective against future infection with Omicron variants such as JN.1, but may still be vulnerable to antigenically advancedsubvariants such as KP.3.1.1 and XEC.Cell Discovery;