(Ebook) Molecular Targets in Protein Misfolding and Neurodegenerative Disease by Pierfausto Seneci ISBN 9780128001868, 0128001860

(Ebook) Molecular Targets in Protein Misfolding and Neurodegenerative Disease by Pierfausto Seneci ISBN 9780128001868, 0128001860

Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseasesProvides a “drug discovery” application oriented perspective, evaluating targets and candidates for their overall therapeutic potentialProvides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical developmentProvides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease areaContains a more thorough description of the therapeutic relevance of ~10 specific molecular targets