(Ebook) Molecular Biology of B Cells 1st Edition by Tasuku Honjo, Frederick W Alt, Michael Neuberger ISBN 0120536412 9780120536412

(Ebook) Molecular Biology of B Cells 1st Edition by Tasuku Honjo, Frederick W Alt, Michael Neuberger ISBN 0120536412 9780120536412

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ISBN 10: 0120536412 
ISBN 13: 9780120536412
Author: Tasuku Honjo, Frederick W Alt, Michael Neuberger

Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.

(Ebook) Molecular Biology of B Cells 1st Table of contents:

Chapter 1: Human Immunoglobulin Heavy Chain Locus
ORGANIZATION OF THE HUMAN VH LOCUS
ANALYSIS OF HUMAN VH SEGMENTS
EVOLUTION OF THE HUMAN VH LOCI
HUMAN CH LOCUS
Chapter 2: Immunoglobulin Heavy Chain Genes of Mouse
Igh-V OR VH GENES OF THE Ighb HAPLOTYPE
POLYMORPHISM IN Vh GENES
EVOLUTION
GENOMIC CONSIDERATIONS
CONCLUSION
Chapter 3: Immunoglobulin κ Genes of Human and Mouse
1. GENERAL FEATURES OF HUMAN AND MOUSE κ GENES
2. HUMAN IMMUNOGLOBULIN κ GENES
3. MOUSE IMMUNOGLOBULIN κ GENES
4. ASPECTS OF EVOLUTION OF THE κ GENES
5. CONCLUDING REMARKS
Acknowledgments
Chapter 4: Immunoglobulin Lambda (IGL) Genes of Human and Mouse
IGL GENES AND IMGT-ONTOLOGY
THE HUMAN IGL GENES
THE MOUSE IGL GENES
CONCLUSION
Chapter 5: The Mechanism of V(D)J Recombination
ANTIGEN RECEPTOR GENE ASSEMBLY
MUTATIONAL ANALYSIS OF RECOMBINATION SIGNAL SEQUENCES
“BEYOND 12/23” RESTRICTION OF V(D)J REARRANGEMENTS
INFLUENCE OF CODING FLANKS
THE BIOCHEMISTRY OF V(D)J CLEAVAGE
RAG1/2-RSS BINDING
RAG1/2 POST-CLEAVAGE COMPLEX
A ROLE FOR HMG1 (OR HMG2) IN V(D)J RECOMBINATION
A CLOSER LOOK AT RAG1 AND RAG2
CODING AND SIGNAL JOINT FORMATION REQUIRES THE NHEJ PATHWAY
Acknowledgments
Chapter 6: Transcription of Immunoglobulin Genes
TRANSCRIPTIONAL REGULATORY ELEMENTS IN IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN GENES
PROTEINS BINDING IN IG TRANSCRIPTIONAL REGULATORY ELEMENTS
AREAS OF CURRENT RESEARCH
DISCOVERIES RESULTING FROM THE STUDY OF IG GENE TRANSCRIPTION
CONCLUSION
Chapter 7: Early B Cell Development to a Mature, Antigen-Sensitive Cell
THREE WAVES OF HEMATOPOIESIS DURING EMBRYONIC DEVELOPMENT
PLURIPOTENT HEMATOPOIETIC STEM CELLS
PATHWAYS OF HEMATOPOIETIC PROGENITOR CELLS TOWARD B LYMPHOCYTE LINEAGE COMMITMENT AND DIFFERENTIATION
CONTROL OF LYMPHOID CELL DEVELOPMENT BY TRANSCRIPTION FACTORS
PLASTICITY OF PAX-5–DEFICIENT PRE-B CELLS
THE SURROGATE LIGHT CHAIN
PRE-B CELLS AND THEIR DIFFERENTIATION TO MORE MATURE B LINEAGE CELLS
REARRANGEMENTS AT THE L CHAIN LOCI AT THE TRANSITION FROM LARGE TO SMALL PRE-B-II CELLS
IMMATURE B CELLS
SELECTIONS OF IMMATURE B CELLS
CONCLUSION
Acknowledgments
Chapter 8: Allelic Exclusion, Isotypic Exclusion, and the Developmental Regulation of V(D)J Recombination
RAG EXPRESSION
THE 12/23 RULE
ACCESSIBILITY HYPOTHESIS
ENHANCER AND PROMOTER CONTROL OF V(D)J RECOMBINATION
TRANS-ACTING FACTORS
CHROMATIN DYNAMICS AND V(D)J RECOMBINATION
ORDERED REARRANGEMENT WITHIN IG AND TCR LOCI
ALLELIC EXCLUSION AT IG AND TCR LOCI
IG LIGHT CHAIN ISOTYPIC EXCLUSION
FUTURE DIRECTIONS
Acknowledgments
Chapter 9: The Development of Human B Lymphocytes
STAGES OF HUMAN B CELL DIFFERENTIATION
SITES OF HUMAN B CELL DEVELOPMENT
HUMAN IMMUNOGLOBULIN GENES
THE ROLE OF SURROGATE LIGHT CHAINS IN HUMAN B CELL DEVELOPMENT
REPERTOIRE DIVERSIFICATION VIA RECEPTOR EDITING AND VH REPLACEMENT
REGULATION OF ANTIBODY PRODUCTION BY B CELL RECEPTORS
IMMUNODEFICIENCY DISEASES
B LINEAGE LEUKEMIA
CONCLUSION
Chapter 10: Development and Function of B Cell Subsets
SELECTION AND DIFFERENTIAL SURVIVAL MECHANISMS—B CELL RECEPTOR SIGNALING
COMPARTMENTALIZATION OF B CELL SUBSETS
OTHER FACTORS INVOLVED IN FORMATION OF B CELL SUBSETS
CONCLUSION
Acknowledgments
Chapter 11: Structure and Function of B Cell Antigen Receptor Complexes
STRUCTURE OF THE BCR COMPLEX
COUPLING BETWEEN THE BCR AND SYK
REDOX REGULATION OF BCR SIGNALING
ITAM- AND NON-ITAM-CONTROLLED SIGNALING PATHWAYS TO SLP-65
ITAM-INDEPENDENT SIGNALING AND FINE-TUNING
CONCLUSION
Chapter 12: Regulation of Antigen Receptor Signaling by the Co-Receptors, CD19 and CD22
CD19
INHIBITORY CO-RECEPTORS ON B CELLS
CONCLUSION
Chapter 13: The Dynamic Structure of Antibody Responses
THREE ROUTES TO ANTIBODY PRODUCTION
STAGES OF ADAPTIVE ANTIBODY RESPONSES
HOW AND WHERE B CELLS ENCOUNTER ANTIGEN
PRIMARY COGNATE INTERACTION OF B CELLS WITH PRIMED T CELLS
EXPONENTIAL GROWTH OF ACTIVATED B CELLS
PROLIFERATION, HYPERMUTATION, AND SELECTION IN GC
SUSTAINED SURVIVAL OF MEMORY B CELL CLONES AND PLASMA CELLS
CONCLUSION
Chapter 14: Dynamics of B Cell Migration to and within Secondary Lymphoid Organs
LYMPHOID ORGAN ENTRY
COMPARTMENTALIZATION OF MATURE B CELLS
B CELLS AT SITES OF INFLAMMATION
HOMING OF ANTIBODY-SECRETING CELLS (ASCs)
CONCLUSION
Chapter 15: Characteristics of Mucosal B Cells with Emphasis on the Human Secretory Immune System
IMMUNE-INDUCTIVE TISSUE COMPARTMENTS
CHARACTERISTICS OF B CELLS IN SECRETORY EFFECTOR TISSUES
B-CELL STIMULATION IN MALT STRUCTURES
CLASS SWITCH AND IgA ISOTYPE PROMOTION
MECHANISMS DIRECTING HOMING AND RETENTION OF MUCOSAL B CELLS
WHAT IS ACTUALLY KNOWN ABOUT HUMAN MUCOSAL B CELLS?
Acknowledgments
Chapter 16: The Cellular Basis of B Cell Memory
GENERATION OF B CELL MEMORY AND MEMORY B CELLS IN T CELL-DEPENDENT ANTIBODY RESPONSES
MEMORY PLASMA CELLS
ADAPTIVE B CELL MEMORY
Acknowledgments
Chapter 17: Immunoglobulin Assembly and Secretion
MECHANISMS OF IG SYNTHESIS AND ASSEMBLY
MULTIPLE LAYERS OF QUALITY CONTROL EXIST TO AID AND MONITOR THE ASSEMBLY OF FUNCTIONAL IGS
TRANSPORT OF ASSEMBLED IG MOLECULES TO THE GOLGI
DEGRADATION OF MISFOLDED AND UNASSEMBLED IG SUBUNITS
DIFFERENTIATION TO PLASMA CELL
CONCLUSION
Acknowledgments
Chapter 18: Fc and Complement Receptors
CONSEQUENCES OF FCγRIIB DEFICIENCY
CONSEQUENCES OF COMPLEMENT AND COMPLEMENT RECEPTOR DEFICIENCIES
Fc RECEPTORS
COMPLEMENT RECEPTORS
CO-RECEPTOR SIGNALING VERSUS ANTIGEN LOCALIZATION TO FDC
FRONTIERS: COMPLEMENT VERSUS Fc RECEPTORS
Chapter 19: Regulation of Class Switch Recombination
CSR REQUIRES SPECIFIC STIMULI OCCURRING IN A DEFINED GERMINAL CENTER (GC) MICROENVIRONMENT
PROXIMAL CIS REGULATORY ELEMENTS FOR GT
A DISTANT REGULATORY REGION FOR GT AND CSR: THE 3’ IGH ENHANCERS
MECHANISMS FOR 3’ IGH REGULATORY REGION-MEDIATED REGULATION OF GT
COORDINATED REGULATION OF TRANSCRIPTION, RECOMBINATION, AND REPLICATION
CONCLUSION
Chapter 20: Molecular Mechanism of Class Switch Recombination
OUTLINE OF MECHANISM FOR CSR
ISOTYPE SPECIFICITY OF CSR
AID, THE SOLE B CELL-SPECIFIC FACTOR REQUIRED FOR CSR
CLEAVAGE OF THE S REGION
PROCESSING AND JOINING OF DNA ENDS AFTER CLEAVAGE
COMPARISON OF CSR WITH SHM
CONCLUSION
Chapter 21: Molecular Mechanism of Hypermutation
CHARACTERISTICS OF SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN VARIABLE REGIONS
ACTIVATION AND TARGETING OF HYPERMUTATION BY TRANSCRIPTION AND CIS-ELEMENTS
HYPERMUTATION OCCURS WITHIN A LIMITED WINDOW OF B CELL DEVELOPMENT
THE AID GENE IS CRITICAL FOR HYPERMUTATION
PHASE ONE OF HYPERMUTATION: C→U DEAMINATION AND BASE EXCISION REPAIR
MISMATCH REPAIR FACTORS IN PHASE TWO OF HYPERMUTATION
DNA BREAKS IN HYPERMUTATION
COMPETING PATHWAYS OF REPAIR: ERROR-PRONE DNA SYNTHESIS OR STRAND TRANSFER
EVOLUTION AND HYPERMUTATION
Chapter 22: Selection During Antigen-Driven B Cell Immune Responses: The Basis for High Affinity Antibody
OVERVIEW OF THE B-CELL IMMUNE RESPONSE
AFFINITY MATURATION IN THE EARLY STAGES OF THE B-CELL IMMUNE RESPONSE
THE GC IS A SECOND MAJOR SITE FOR AFFINITY MATURATION
AFFINITY-BASED SELECTION CONTINUES AFTER THE GC REACTION HAS ENDED
AN INTEGRATED VIEW OF THE STRATEGIC DESIGN OF THE B-CELL IMMUNE RESPONSE: FUTURE DIRECTIONS
Acknowledgments
Chapter 23: Chromosomal Translocations in B-Cell Leukemias and Lymphomas
TRANSLOCATIONS ASSOCIATED WITH A BLOCK IN LYMPHOID DIFFERENTIATION
TRANSLOCATIONS ASSOCIATED WITH SUPPRESSION OF APOPTOSIS DURING LYMPHOID DEVELOPMENT
TRANSLOCATIONS INVOLVING THE NFKB PATHWAY
TRANSLOCATIONS ASSOCIATED WITH INCREASED PROLIFERATION IN LYMPHOID PRECURSORS
CONCLUSION
Chapter 24: Classification and Characteristics of Mouse B Cell—Lineage Lymphomas
COMPARATIVE CLASSIFICATIONS OF MOUSE AND HUMAN B CELL–LINEAGE NEOPLASMS
CHARACTERISTICS OF MOUSE B CELL–LINEAGE LYMPHOMAS
PATHOGENESIS
CONCLUSION
Chapter 25: B Cells Producing Pathogenic Autoantibodies
SUBSETS OF AUTOANTIBODIES
CRITERIA TO DEFINE PATHOGENIC AUTOANTIBODIES
GENETICS OF AUTOANTIBODIES
MOLECULAR AND IMMUNOCHEMICAL CHARACTERISTICS OF HUMAN PATHOGENIC AUTOANTIBODIES
HUMAN PATHOGENIC AUTOANTIBODIES WITH MURINE COUNTERPARTS
CONCLUSION
Acknowledgments
Chapter 26: Immunodeficiencies Caused by B-Cell Defects
CLINICAL FEATURES OF THE AGAMMAGLOBULINEMIAS
AUTOSOMAL RECESSIVE HYPER-IGM SYNDROME
MURINE MODELS OF HUMAN B-CELL DEFICIENCY
CONCLUSION
Chapter 27: Diverse Forms of Immunoglobulin Genes in Lower Vertebrates
CARTILAGINOUS FISH: AN UNUSUAL EXAMPLE OF GENE MULTIPLICITY
BONY FISH: IG HEAVY CHAIN GENES RESEMBLE IGM AND IGD
LOBE-FINNED FISH: A “TRANSITIONAL” ARRANGEMENT OF RECOMBINING ELEMENTS
FLESHY-FINNED FISH: AN ANCIENT ORIGIN FOR ISOTYPE DIVERSITY
AMPHIBIANS AND REPTILES: THE POSSIBLE ORIGINS OF CLASS SWITCHING
LIGHT CHAIN GENES: DIVERSE STRUCTURES AND ORGANIZATION IN LOWER VERTEBRATES
TRANSCRIPTIONAL CONTROL OF IG GENES IN LOWER VERTEBRATES
A UNIFYING HYPOTHESIS TO EXPLAIN THE ORIGINS OF THE ADAPTIVE IMMUNE RECEPTOR
IMMUNE MOLECULES IN JAWLESS VERTEBRATES
PROTOCHORDATES: DIFFERENT CONTEXTS FOR DIVERSIFIED V REGIONS
Chapter 28: Immunoglobulin Genes and Generation of Antibody Repertoires in Higher Vertebrates: A Key Role for GALT
AVIANS
LAGOMORPHS
ARTIODACTYLS
OTHER MAMMALS
CONCLUSION
Chapter 29: The Zebrafish Immune System
HEMATOPOIESIS
ADAPTIVE IMMUNITY IN ZEBRAFISH: ORGANS AND MOLECULES
GENETIC APPROACHES
MAJOR HISTOCOMPATABILITY COMPLEX (MHC)
INNATE IMMUNITY
INFECTION
CONCLUDING REMARKS: ZEBRAFISH AND HUMAN DISEASE
Chapter 30: The Origin of V(D)J Diversification
THE ALIEN SEED
THE EVOLUTION OF BCR AND TCR LOCI
CONSIDERATIONS ON THE UR-V GENE
Chapter 31: Antibody Structure and Recognition of Antigen
A STRUCTURAL FRAMEWORK FOR MOLECULAR RECOGNITION
THE ROLES OF CONFORMATIONAL FLEXIBILITY IN ANTIGEN RECOGNITION
BINDING ENERGETICS OF ANTIBODY–ANTIGEN INTERACTIONS
MAPPING THE ANTIBODY–ANTIGEN ENERGETIC LANDSCAPE THROUGH MUTAGENESIS
ACCOMMODATION OF MUTATIONS IN THE ANTIBODY–ANTIGEN INTERFACE
CROSS-REACTIVITY AND SPECIFICITY OF ANTIGEN RECOGNITION
MODEL SYSTEMS FOR PROBING FUNDAMENTAL RULES OF MOLECULAR INTERACTIONS
TOWARD A STRUCTURAL BASIS OF ANTIBODY AFFINITY MATURATION
BREAKING THE AFFINITY CEILING THROUGH IN VITRO EVOLUTION
CONCLUSION
Chapter 32: Monoclonal Antibodies from Display Libraries
OVERVIEW OF ANTIBODY PHAGE DISPLAY
PROKARYOTIC EXPRESSION OF ANTIBODY FRAGMENTS
GENERATION OF ANTIBODY GENE REPERTOIRES USING THE POLYMERASE CHAIN REACTION
ANTIBODY PHAGE DISPLAY
USE OF PHAGE DISPLAY TO BYPASS HYBRIDOMA TECHNOLOGY
USE OF PHAGE DISPLAY TO BYPASS IMMUNIZATION
A COMPARISON OF DIFFERENT PHAGE ANTIBODY LIBRARY TYPES AND APPLICATIONS
STRATEGIES FOR SELECTION OF PHAGE ANTIBODIES
INCREASING ANTIBODY AFFINITY USING PHAGE DISPLAY
ALTERNATIVE ANTIBODY DISPLAY TECHNOLOGIES
CONCLUSION
Chapter 33: Humanization of Monoclonal Antibodies
MURINE, CHIMERIC, AND HUMANIZED ANTIBODIES
COMPUTER-GUIDED DESIGN OF HUMANIZED V REGIONS
OTHER HUMANIZATION METHODS
IMMUNOGENICITY OF HUMANIZED ANTIBODIES
HUMANIZED ANTIBODIES APPROVED FOR CLINICAL USE
CONCLUSION
Chapter 34: Human Monoclonal Antibodies from Translocus Mice
HUMAN IG TRANSLOCI
THE MOUSE STRAINS
CONCLUSION
Index

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