(Ebook) Micro and Nanoengineering of the Cell Microenvironment Technologies and Applications 1st edition by Ali Khademhosseini, Jeffrey Borenstein, Mehmet Toner 1596931493 9781596931497

(Ebook) Micro and Nanoengineering of the Cell Microenvironment Technologies and Applications 1st edition by Ali Khademhosseini, Jeffrey Borenstein, Mehmet Toner 1596931493 9781596931497

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ISBN-10 :  1596931493 

ISBN-13 :  9781596931497

Author: Ali Khademhosseini, Jeffrey Borenstein, Mehmet Toner 

This groundbreaking work puts you at the cutting edge of diagnostic and therapeutic bioengineering, and brings you up to speed with the extraordinary range of cell-based biomedical applications now in development. Written by pioneers in the field, it explores the top-down and bottom-up technologies that can be used to control various aspects of the stem cell microenvironment. The book shows how these microfabrication and material synthesis techniques are paving the way to dramatic clinical breakthroughs in areas ranging from in vitro fertilization to artificial skin and organ tissue generation. Supported with 140 illustrations, the volume exhaustively covers the micro- and nano-system technologies involved in developing cell-based bioengineering applications. You get full details on efforts to engineer the soluble and insoluble cell microenvironments, including the latest advances in microfluidic devices, surface patterning, 3D scaffolds, and techniques for engineering cellular mechanical properties and topography. The book systematically reviews emerging biomedical applications, including the latest in embryonic cell development, microfabrication of artificial neural tissue, and microvascular and cardiac tissue engineering. What’s more, this comprehensive resource covers hydrogels for cartilage tissue, bone tissue engineering, kidney replacement therapies, and pulmonary applications. Moreover, the book presents the latest advances in hepatic tissue engineering, immune cell analysis, and the development of engineered skin substitutes.

Micro and Nanoengineering of the Cell Microenvironment : Technologies and Applications 1st table of contents:

Chapter 1 Micro- and Nanoengineering the Cellular Microenvironment
1.1 Introduction
1.2 Cellular Microenvironment
1.3 Controlling Cellular Behavior
1.4 Micro- and Nanoengineering the Cellular Microenvironment
1.5 Book Structure
References
Chapter 2 Gradient-Generating Microfluidic Devices for Cell Biology Research
2.1 Introduction
2.2 Conventional Devices for Soluble Gradient Generation
2.3 Microfluidic-Based Devices for Gradient Generation
2.4 Biological Applications of Gradient-Generating Microfluidic Devices
2.5 Summary and Future Directions
References
Chapter 3 Surface Patterning for Controlling Cell-Substrate Interactions
3.1 Introduction
3.2 Self-Assembled Monolayers, Lithography, and Other Important Tools
3.3 Controlling the Adsorption of Proteins on Surface
3.4 Patterning of Proteins and Cells
3.5 Dynamic Patterning of Cells
3.6 Other Systems for Patterning Cells
3.7 Conclusion
References
Chapter 4 Patterned Cocultures for Controlling Cell-Cell Interactions
4.1 Introduction
4.2 Random Coculture Systems
4.3 Patterned Coculture Systems
4.4 Conclusion
References
Chapter 5 Micro- and Nanofabricated Scaffolds for Three-Dimensional Tissue Recapitulation
5.1 Introduction
5.2 Microfabricated Interfaces
5.3 Nanofabricated Interfaces
5.4 Conclusion
References
Chapter 6 Biomimetic Hydrogels to Support and Guide Tissue Formation
6.1 Introduction
6.2 Hydrogels and Their Synthesis
6.3 Incorporating Bioactive Factors into Hydrogels
6.4 Two-Dimensional Patterning of Hydrogels
6.5 Three-Dimensional Rapid Prototyping of Hydrogels
6.6 Summary
References
Chapter 7 Three-Dimensional Cell-Printing Technologies for Tissue Engineering
7.1 Overview
7.2 Development of Cell-Printing Technologies
7.3 Conventional Three-Dimensional Cell-Printing Methods
7.4 Current Applications of Cell-Printing Technology: Organ Printing
7.5 Other Applications of Cell Printing
7.6 Technologies for Three-Dimensional Cell Printing: Single Cell Epitaxy by Acoustic Picoliter Drop
7.7 Conclusion
References
Chapter 8 Using Microfabrication to Engineer Cellular and Multicellular Architecture
8.1 Introduction
8.2 Patterning Adhesion
8.3 Patterning Single Cells
8.4 Multicellular Patterning
8.5 Engineering Single Cell-Cell Interactions
8.6 Cell Patterning by Active Positioning: Dielectrophoresis and Microfluidics
8.7 Three-Dimensional Patterning
8.8 Future Directions
References
Chapter 9 Technologies and Applications for Engineering Substrate Mechanics to Regulate Cell Respons
9.1 Introduction
9.2 How Cells Sense the Stiffness of Their Substrate
9.3 Technologies to Engineer the Mechanical Properties of the Substrate
9.4 Effects of Substrate Mechanics on Cell Response
9.5 Summary and Future Challenges
References
Chapter 10 Engineered Surface Nanotopography for Controlling Cell-Substrate Interactions
10.1 Introduction
10.2 Methods for Generating Nanotopography
10.3 Topical Issues in Controlling Cell-Substrate Interactions
10.4 Conclusion
References
Chapter 11 Microfluidics for Assisted Reproductive Technologies
11.1 Introduction
11.2 Micro-/Nanotechnology
11.3 Conclusions and Future Directions
References
Chapter 12 Microscale Technologies for Engineering Embryonic Stem Cell Environments
12.1 Embryonic Stem Cells
12.2 Microscale Technologies
12.3 Conclusion
References
Chapter 13 Neuroscience on a Chip: Microfabrication for In Vitro Neurobiology
13.1 Introduction
13.2 Microengineered Neurite Growth and Neuronal Polarity
13.3 Microengineered Cell-Cell Signaling
13.4 Conclusions and Future Directions
References
Chapter 14 Self-Assembly of Nanomaterials for Engineering Cell Microenvironment
14.1 Overview
14.2 Proteins and Peptides
14.3 Self-Assembly of Proteins and Peptides
14.4 Findings About Amphiphilic and Surfactantlike Peptides
14.5 Findings About Three-Dimensional Peptide Matrix Scaffolds
14.6 Use of Peptide Hydogels in Regenerative Biology and Three-Dimensional Cell Culture
14.7 Applications of Synthetic Amphiphilic Peptides in Other Fields of Nanotechnology
14.8 Conclusion
References
Chapter 15 Microvascular Engineering: Design, Modeling, and Microfabrication
15.1 Introduction
15.2 Design of Microvascular Networks
15.3 Computational Models for Microvascular Networks
15.4 Microfabrication Technology for Vascular Network Formation
15.5 Conclusion
References
Chapter 16 Nanotechnology for Inducing Angiogenesis
16.1 Introduction
16.2 Nanostructured Scaffolds and Angiogenesis
16.3 Functionalized Smooth Surfaces and Angiogenesis
16.4 Conclusion
References
Chapter 17 Micropatterning Approaches for Cardiac Biology
17.1 Introduction
17.2 Isolation and Culture of Cardiac Myocytes
17.3 Engineering the Cellular Microenvironment In Vitro
17.4 Traction Force Microscopy for Cardiac Myocytes
17.5 Conclusions and Future Perspectives
References
Chapter 18 Microreactors for Cardiac Tissue Engineering
18.1 Introduction
18.2 Patterned Cardiomyocyte Cultures in Two Dimensions
18.3 Patterned Cardiomyocyte Cultures in Three Dimensions
18.4 Microsystems for Co- and Tricultures in Two and Three Dimensions
18.5 Microbioreactors for Culture of Cardiac Organoids
18.6 Microfluidic Devices for Cardiac Cell Separation
18.7 Looking Forward
18.8 Conclusion
References
Chapter 19 Nanoengineered Hydrogels for Stem Cell Cartilage Tissue Engineering
19.1 Hydrogel Microenvironments
19.2 Stem Cell Encapsulation in Hydrogels
19.3 Coculture Microenvironments for Directing Stem CellDifferentiation and Tissue Development
References
Chapter 20 Microscale Approaches for Bone Tissue Engineering
20.1 Introduction
20.2 Importance of Cell-Cell Interactions for Regulating Osteogenesis
20.3 Use of Substrate Properties to Control Osteogenesis
20.4 Techniques for Translating Two-Dimensional Systems to Three-Dimensional Scaffolds
20.5 Conclusion
References
Chapter 21 Nanoengineering for Bone Tissue Engineering
21.1 Introduction
21.2 The Role of Nanomaterials in Orthopedic Implants
21.3 Future Challenges
References
Chapter 22 Bioinspired Engineered Nanocomposites for Bone Tissue Engineering
22.1 Introduction
22.2 Bone Structure
22.3 Degradable Polymers as Scaffolds for Bone Regeneration
22.4 Degradable Composite Scaffolds for Bone Regeneration
22.5 Collagen nanostructure and its effect on differentiation of bone marrow stromal cells
22.6 Biomimetic Hydrogel Nanocomposites for Bone Regeneration
22.7 Conclusion
References
Chapter 23 Technological Approaches to Renal Replacement Therapies
23.1 Introduction
23.2 Kidney Functioning Overview
23.3 Kidney Failure
23.4 Treatments
23.5 History of Hemodialysis
23.6 Dialyzer Improvements
23.7 Innovative Hemodialysis Approaches
23.8 Conclusion
References
Chapter 24 Engineering Pulmonary Epithelia and Their Mechanical Microenvironments
24.1 Introduction
24.2 The Lung and Pulmonary Epithelial Cells
24.3 In Vitro Production and Engineering of Pulmonary Epithelium
24.4 Engineering of Cell-Matrix and Cell-Cell Interactions
24.5 Engineering of Cell-Fluid Interactions
24.6 Measurements of Mechanically Induced Inflammatory Responses
24.7 Conclusion
References
Chapter 25 Microfabricated Systems for Analyzing Immune-Cell Functions
25.1 Introduction
25.2 Micro- and Nanopatterned Surfaces as Tools to Dissect Immune-Cell Functions
25.3 Single-Cell Microarrays: Microwells and Microchambers fo rAssaying the Functions of Individual
25.4 Control of Immune-Cell Migration in Model Microenvironments
25.5 Conclusions and Outlook
References
Chapter 26 Microscale Hepatic Tissue Engineering
26.1 Introduction
26.2 Strategies for Developing Stable Hepatocyte Culture Models
26.3 Bioartificial Liver Devices
26.4 Hepatic Constructs for Transplantation
26.5 Liver-Cell Microarrays
26.6 Summary
References
Chapter 27 Nano- and Microtechnologies for the Development of Engineered Skin Substitutes
27.1 Overview
27.2 Nano- and Microscale Approaches to Producing Engineered Skin Substitutes
27.3 Nano- and Microscale Approaches for Controlling Cellular Microenvironments
27.4 Future Considerations

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Tags: Micro, Nanoengineering, the Cell Microenvironment, Technologies, Applications, Ali Khademhosseini, Jeffrey Borenstein, Mehmet Toner