Meningeal lymphatic drainage: novel insights into central nervous system disease by Qiang Zhang & Yin Niu & Yingpei Li & Chenyang Xia & Zhi Chen & Yujie Chen & Hua Feng instant download

Meningeal lymphatic drainage: novel insights into central nervous system disease by Qiang Zhang & Yin Niu & Yingpei Li & Chenyang Xia & Zhi Chen & Yujie Chen & Hua Feng instant download

In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervoussystem (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainagedysfunction include neurodegenerative diseases, stroke, infections, traumatic brain injury, tumors, functional cranial disorders, andhydrocephalus. However, the understanding of the regulatory and damage mechanisms of meningeal lymphatics underphysiological and pathological conditions is currently limited. Given the importance of a profound understanding of the interplaybetween meningeal lymphatic drainage and CNS diseases, this review covers seven key aspects: the development and structure ofmeningeal lymphatic vessels, methods for observing meningeal lymphatics, the function of meningeal lymphatics, the molecularmechanisms of meningeal lymphatic injury, the relationships between meningeal lymphatic vessels and CNS diseases, potentialregulatory mechanisms of meningeal lymphatics, and conclusions and outstanding questions. We will explore the relationshipbetween the development, structure, and function of meningeal lymphatics, review current methods for observing meningeal1234567890();,:lymphatic vessels in both animal models and humans, and identify unresolved key points in meningeal lymphatic research. The aimof this review is to provide new directions for future research and therapeutic strategies targeting meningeal lymphatics bycritically analyzing recent advancements in the field, identifying gaps in current knowledge, and proposing innovative approachesto address these gaps.Signal Transduction and Targeted Therapy (2025) 10:142 ;