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EbookNice Team
Status:
Available4.8
26 reviewsISBN 10: 0521113768
ISBN 13: 9780521113762
Author: David Boal
Exploring the mechanical features of biological cells, including their architecture and stability, this textbook is a pedagogical introduction to the interdisciplinary fields of cell mechanics and soft matter physics from both experimental and theoretical perspectives. This second edition has been greatly updated and expanded, with new chapters on complex filaments, the cell division cycle, the mechanisms of control and organization in the cell, and fluctuation phenomena. The textbook is now in full color which enhances the diagrams and allows the inclusion of new microscopy images. With around 280 end-of-chapter exercises exploring further applications, this textbook is ideal for advanced undergraduate and graduate students in physics and biomedical engineering. A website hosted by the author contains extra support material, diagrams and lecture notes, and is available at www.cambridge.org/Boal.
1 Introduction to the cell
1.1 Designs for a cell
1.2 Cell shapes, sizes and structures
1.3 Biomaterials: soft strings and sheets
1.4 Forces inside and outside the cell
Summary
2 Soft materials and fluids
2.1 Fluctuations at the cellular scale
2.2 Movement in a viscous fluid
2.3 Random walks
2.4 Diffusion
2.5 Fluctuations and correlations
Summary
Problems
Part I Rods and ropes
3 Polymers
3.1 Polymers and simple biofilaments
3.2 Mathematical description of flexible rods
3.3 Sizes of polymer chains
3.4 Entropic elasticity
3.5 Buckling
3.6 Measurements of bending resistance
Summary
Problems
4 Complex filaments
4.1 The structure of complex filaments
4.2 Torsion, twist and writhe
4.3 Measurements of torsional rigidity
4.4 Stretching of folded polymers
4.5 Protein and RNA folding – concepts
4.6 Models for polymer folding
Summary
Problems
5 Two-dimensional networks
5.1 Soft networks in the cell
5.2 Elasticity in two dimensions
5.3 Isotropic networks
5.4 Networks with low coordination number
5.5 Membrane-associated networks
Summary
Problems
6 Three-dimensional networks
6.1 Networks of biological rods and ropes
6.2 Elasticity in three dimensions
6.3 Entropic networks
6.4 Network percolation and failure
6.5 Semiflexible polymer solutions
6.6 Rheology of cytoskeletal components
Summary
Problems
Part II Membranes
7 Biomembranes
7.1 Membranes, walls and lamina
7.2 Self-assembly of amphiphiles
7.3 Bilayer compression resistance
7.4 Bilayer bending resistance
7.5 Edge energy
7.6 Cell walls and sheaths
Summary
Problems
8 Membrane undulations
8.1 Thermal fluctuations in membrane shape
8.2 Mathematics of curvature
8.3 Membrane bending and persistence length
8.4 Scaling of polymers and membranes
8.5 Measurement of membrane undulations
Summary
Problems
9 Intermembrane and electrostatic forces
9.1 Interactions between membranes
9.2 Charged plate in an electrolyte
9.3 van der Waals and electrostatic interactions
9.4 Entropic repulsion of sheets and polymers
9.5 Adhesion
Summary
Problems
Part III The whole cell
10 The simplest cells
10.1 Cell shapes
10.2 Energetics of thin shells
10.3 Pure bilayer systems
10.4 Vesicles and red blood cells
10.5 Bacteria
Summary
Problems
11 Dynamic filaments
11.1 Movement in the cell
11.2 Polymerization of actin and tubulin
11.3 Molecular motors
11.4 Forces from filaments
11.5 Cell propulsion
Summary
Problems
12 Growth and division
12.1 Overview of the division cycle
12.2 Growth of rods and cocci
12.3 Asymmetry and asynchrony in cell division
12.4 Transcription and replication
12.5 Forces arising in cell division
Summary
Problems
13 Signals and switches
13.1 Axons and the action potential
13.2 Signal propagation in nerves
13.3 Rate equations: switches and stability
13.4 Molecular basis of regulation
Summary
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Tags: David Boal, Mechanics, Cell