(Ebook) Mass spectrometry in biophysics: conformation and dynamics of biomolecules by Igor A. Kaltashov, Stephen J. Eyles ISBN 9780471456025, 0471456020

(Ebook) Mass spectrometry in biophysics: conformation and dynamics of biomolecules by Igor A. Kaltashov, Stephen J. Eyles ISBN 9780471456025, 0471456020

"Recent advances in mass spectrometry (MS) have pushed the frontiers of analytical chemistry into the biophysical laboratory. As a result, the biophysical community's acceptance of MS-based methods, used to study protein higher-order structure and dynamics, has accelerated the expansion of biophysical MS." "Despite this growing trend, until now no single text has presented the full array of MS-based experimental techniques and strategies for biophysics. Mass Spectrometry in Biophysics expertly closes this gap in the literature."."Covering the theoretical background and technical aspects of each method, this much-needed reference offers an unparalleled overview of the current state of biophysical MS. Mass Spectrometry in Biophysics begins with a helpful discussion of general biophysical concepts and MS-related techniques." "Fully referenced and containing a helpful appendix on the physics of electrospray mass spectrometry, Mass Spectrometry in Biophysics also offers a compelling look at the current challenges facing biomolecular MS and the potential applications that will likely shape its future."--BOOK JACKET. Read more... Content: General overview of basic concepts in molecular biophysics. -- Overview of "traditional" experimental arsenal to study biomolecular structure and dynamics. -- Overview of biological mass spectrometry. -- Mass spectrometry-based approaches to study biomolecular higher-order structure. -- Mass spectrometry-based approaches to study biomolecular dynamics equilibrium intermediates. -- Kinetic studies by mass spectrometry. -- Protein interaction: a closer look at "structure-dynamics-function" triad. -- Synergism between biophysical techniques. -- Other biopolymers and synthetic polymers of biological interest. -- Biomolecular ions in a solvent-free environment. -- Mass spectrometry on the march: where next? From molecular biophysics to structural biology, perspectives and challenges. -- Appendix: Physics of electrospray. Abstract: "Recent advances in mass spectrometry (MS) have pushed the frontiers of analytical chemistry into the biophysical laboratory. As a result, the biophysical community's acceptance of MS-based methods, used to study protein higher-order structure and dynamics, has accelerated the expansion of biophysical MS." "Despite this growing trend, until now no single text has presented the full array of MS-based experimental techniques and strategies for biophysics. Mass Spectrometry in Biophysics expertly closes this gap in the literature."."Covering the theoretical background and technical aspects of each method, this much-needed reference offers an unparalleled overview of the current state of biophysical MS. Mass Spectrometry in Biophysics begins with a helpful discussion of general biophysical concepts and MS-related techniques." "Fully referenced and containing a helpful appendix on the physics of electrospray mass spectrometry, Mass Spectrometry in Biophysics also offers a compelling look at the current challenges facing biomolecular MS and the potential applications that will likely shape its future."--BOOK JACKET