(Ebook) Lung Biology in Health Disease Volume 186 Pleural Disease 1st Edition by Demosthenes Bouros ISBN 978-0367384562 ‎ 0367384566

(Ebook) Lung Biology in Health Disease Volume 186 Pleural Disease 1st Edition by Demosthenes Bouros ISBN 978-0367384562 ‎ 0367384566

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Product details: 

ISBN 10: 0367384566

ISBN 13: 978-0367384562  ‎

Author: Demosthenes Bouros

Updated to reflect the latest scientific advances and technologies in the diagnosis and treatment of pleural diseases, this new Second Edition explores the structure and function of these diseases and malignancies, from tuberculosis and asbestos to pleurisy and pneumothorax. Edited by leading international authorities in pulmonary medicine, this comprehensive guide is an invaluable resource for pulmonologists, radiologists, and critical care physicians.

Pleural Disease, Second Edition highlights:

molecular and diagnostic approaches

interventional applications, including pleural thoracentesis and closed biopsy, chest tube insertion, pleural lavage, medical thoracoscopy, and VATS

biomarkers and proteomics

translational medicine approaches, new treatment methodologies, and clinical manifestations

various diagnostic tests and the importance of clinical evaluation in the differential diagnosis of a pleural effusion

new surgical and non-surgical techniques to identify and diagnose pleural diseases, including: medical thoracoscopy, pleural lavage, intrapleural fibrinolytics, image-guided

small bore catheters, video-assisted thoracoscopic surgery (VATS), pleuroperitoneal shunt, and extrapleural pneumonectomy

Table of contents: 

1. Reactive Oxygen/Nitrogen Species: Generation and Reactions in the Lung
Ann E. Aust

• Introduction

• Reactive Oxygen Species

• Reactive Nitrogen Species

• Further Reactions of ROS and RNS with Biological Molecules

• Conclusions

• References

2. Oxidative Stress/Antioxidant Status in Health and Disease
Val Vallyathan

• Introduction

• Antioxidants in Normal Healthy Lung

• Antioxidants in Lung Diseases

• Oxidative Stress and Antioxidant Genes

• Pharmacological Modulation and Clinical Benefits

• Conclusions

• References

3. Reactive Oxygen Species in the Activation and Regulation of Intracellular Signaling Events
Fei Chen and Vincent Castranova

• Introduction

• Sources of ROS

• ROS and Signal Transduction

• Is p53 Regulated by or a Regulator for ROS?

• ROS Regulation of Nuclear Factor of Activated T Cells

• Summary

• References

4. Mediators of Lung Inflammation: Role of Reactive Oxygen and Nitrogen Species
Jayne S. Reuben, Ren-Feng Guo, and Peter A. Ward

• Introduction

• Immune Complex-Induced Injury as a Model for Oxidant-Mediated Lung Inflammation

• Superoxide and Oxygen Radicals

• Nitric Oxide

• Proteases

• Endogenous Mediators: Cytokines, Transcription Factors, Chemokines, and Adhesion Molecules

• Role of C5a in Acute Lung Inflammation

• Clinical Relevance

• Conclusions

• References

5. Pulmonary Complications of Chronic Granulomatous Disease
Bernard M. Babior

• Introduction

• Molecular Basis of CGD and Defects in Oxidative Metabolism

• References

6. Genotoxic and Carcinogenic Mechanisms of Mineral Fibers: Role of Reactive Oxygen Species
Tom K. Hei, Ann Xu, and Yongliang Zhao

• Introduction

• Asbestos as a Gene and Chromosomal Mutagen

• Fiber-Cell Interaction in Mediating Genotoxic Response

• Detection of Oxy Radicals Produced by Asbestos Fibers

• Effect of Depleted Intracellular Glutathione Level on Fiber Mutagenesis

• Induction of Oxidative DNA Damage by Asbestos Fibers

• Types of Mutations Induced by Asbestos Are Similar to Those of Hydrogen Peroxide

• Transformation Studies with Human Epithelial Cells

• Gene Expression Profile in Asbestos-Induced Tumor Cells

• Ectopic Expression of the Big-h3 Gene Suppressive Tumorigenicity

• Conclusion

• References

7. Influence of Mineral Dust Surface Characteristics and Generation of Reactive Species
David W. Kamp and Val Vallyathan

• Introduction

• Asbestos

• Phyllosilicates and Coal

• Conclusions

• References

8. Oxygen/Nitrogen Radicals and Silica-Induced Diseases
Vincent Castranova and Val Vallyathan

• Introduction

• Generation of Reactive Oxygen Species from Crystalline Silica

• Generation of Reactive Oxygen Species from Lung Cells Exposed to Silica

• Nitric Oxide Production by Lung Cells

• Summary

• References

9. Asbestosis and Asbestos-Related Cancers: Role of Reactive Oxygen and Nitrogen Species
Arti Shukla and Brooke T. Mossman

• Introduction

• Diseases Caused by Asbestos

• Generation of ROS/RNS by Asbestos

• Role of ROS/RNS in Asbestos-Associated Cellular Effects

• Asbestos-Induced RNS Generation and Pulmonary Toxicity

• Summary

• References

10. Interactions of Exogenous or Evoked Reactive Oxygen Species and Inhaled Particles in the Lung
Andrew Churg

• Introduction

• Adhesion of Particles to Epithelial Cells

• Particle Uptake and Retention by Epithelial Cells

• Exogenous or Evoked ROS and Pathological Reactions to Particles

• Conclusions

• References

11. Smoking-Induced Inflammation, Injury, and Disease: Molecular Mechanisms
Irfan Rahman

• Introduction

• Cigarette Smoke and Oxidative Stress

• ROS-Mediated Lipid Peroxidation Products and Their Role in Biochemical Processes

• Involvement of Cigarette Smoke-Mediated Lipid Peroxidation Products in Cell Signaling and Gene Transcription

• Role of ROS and Cigarette Smoke-Induced Oxidative Stress in Chromatin Modeling: Role for Histone Acetylation/Deacetylation and DNA Methylation

• Conclusions

• References

12. Respiratory Health Effects of Ambient Air Pollution Particles: Role of Reactive Species
Ken Donaldson, L. Albert Jiménez, Irfan Rahman, Stephen P. Faux, William MacNee, Peter S. Gilmour

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Tags: Demosthenes Bouros, Lung Biology, Health Disease