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12 reviewsFlexible deep brain neural interfaces, as an important research direction in the field of neural engineering,have broad application prospects in areas such as neural signal detection, treatment of neurological1234567890():,;1234567890():,;diseases, and intelligent control systems. However, chronic inflammatory responses caused by longterm implantation and the resulting electrode failure seriously hinder the clinical development of thistechnology. This review systematically explores the long-term stability issues of flexible deep brain neuralinterfaces, with a focus on analyzing the synergistic optimization of electrode geometric morphology andimplantation strategies in regulating inflammatory responses. Additionally, this paper delves intoinnovative strategies, such as passive enhancement of biocompatibility through electrode surfacefunctionalization and active inhibition of inflammation through drug-controlled release systems, offeringnew technical paths to extend electrode lifespan. By integrating and reviewing existing innovativemethods for deep brain flexible electrodes, this study provides an important theoretical foundation andtechnical guidance for the development of high-stability neural interface devices.