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34 reviewsSUMMARYTumor-antigen-specific CD8+ T cells (CTLs) are the main effector immunocytes in anti-tumor immunity, buttheir systemic deployment against cancer metastasis remains uncharacterized. Here, we found that the abundance of tumor-specific CD103+CD8+ T cells in the tumor-draining lymph nodes (TDLNs) was associated withimproved lung-metastasis-free survival in breast cancer patients. In mouse cancer models, CD103+CD8+T cells were primed in TDLNs and recruited to the lungs via C-C motif chemokine ligand 5/receptor 9(CCL25/CCR9) signaling to inhibit metastasis through antigen-specific immunity. Furthermore, extracellularvesicles (EVs) from early- and late-stage tumors differentially polarized alveolar macrophages to releaseCCL25 and IDO1, respectively, and the latter impaired pulmonary CD103+CD8+ T cell deployment, facilitatinglung metastasis. Depleting IDO1 effectively rescued CD103+CD8+ T cell-mediated protection against lungmetastasis. These findings exemplified long-range deployment of adaptive immunity to protect distant organsfrom metastasis, highlighting the therapeutic potential of reconstituting effector immune cell deployment(EICD) for cancer treatment.