Kinase inhibitor drugs by Li, Rongshi, Ph. D; Stafford, Jeffrey A instant download

Kinase inhibitor drugs by Li, Rongshi, Ph. D; Stafford, Jeffrey A instant download

xv, 510 p., [16] p. of plates : 25 cm, Includes bibliographical references and index, The discovery and development of sunitinib (SU11248) : a multitarget tyrosine kinase inhibitor of tumor growth, survival, and angiogenesis / Connie L. Sun, James G. Christensen, and Gerald McMahon -- Tykerb discovery : a dual EGFR and ERBB2 tyrosine kinase inhibitor / Karen Lackey and G. Stuart Cockerill -- Discovery of pazopanib : a pan vascular endothelial growth factor kinase inhibitor / Philip A. Harris and Jeffrey A. Stafford -- The road to ABT-869 : a multitargeted receptor tyrosine kinase inhibitor / Michael Michaelides and Daniel H. Albert -- Discovery of motesanib / Andrew S. Tasker and Vinod F. Patel -- Discovery of brivanib alaninate : a dual vascular endothelial growth factor and fibroblast growth factor receptor inhibitor / Rajeev S. Bhide and Joseph Fargnoli -- Structure-based design and characterization of axitinib / Robert S. Kania -- The road to PD0325901 and beyond : the MEK inhibitors quest / Judith S. Sebolt-Leopold and Alexander J. Bridges -- Discovery of allosteric MEK inhibitors / Eli Wallace and James F. Blake -- Discovery of MK-0457 (VX-680) / Julian M.C. Golec -- Discovery of PHA-739358 / Daniele Fancelli and Jürgen Moll -- Discovery of AZD1152 : a selective inhibitor of aurora-B kinase with potent antitumor activity / Kevin M. Foote and Andrew A. Mortlock -- Case study of aurora-A inhibitor MLN8054 / Christopher F. Claiborne and Mark G. Manfredi -- Discovery of GSK461364 : a polo-like kinase 1 inhibitor for the treatment of cancer / Kevin W. Kuntz and Kyle A. Emmitte -- Pharmacogenomics of dasatinib (Sprycel) / Fei Huang and Edwin A. Clark -- Practical use of computational chemistry in kinase drug discovery / James M. Veal -- Approaches to kinase homology modeling : successes and consideration for the structural kinome / Victoria A. Feher and J. David Lawson -- Fragment-based drug discovery of kinase inhibitors / Daniel A. Erlanson -- Protein kinase…