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35 reviewsabstract Article history: Introduction: Kaempferol (KAE) is a flavonoid found in various plants. Recent studies showed that high Received 7 June 2024 dietary intake of KAE was associated with a lower risk of myocardial infarction; however, the cardioproRevised 18 October 2024 tective mechanism of KAE remains unknown. Accepted 30 October 2024 Objectives: To determine the effect of KAE on cardiac injury in isoproterenol (ISO)-induced rats and cobalt Available online xxxx chloride (CoCl2)-treated cardiomyocytes, and the underlying mechanisms. Keywords: Methods: Male rats were pretreated with different doses of KAE for 14 days, and then injected with ISO to induce myocardial ischemia injury. We also established a model of myocardial cell injury using rat H9c2 Kaempferol cardiomyocytes stimulated with CoCl2. HDAC3 Results: We found that KA E pretreatment significantly alleviated myocardial injury and improved cardiac Nrf2 function in ISO-injected ra ts. In addition, KAE reduced oxidative stress in rats with myocardial ischemia Oxidative stress Cardiac injury by decreasing malondiald ehyde concentration and increasing superoxide dismutase activity, and protection of the myocardial mi tochondrial structure. KAE also attenuated CoCl2-induced injury of H9c2 cardiomyocytes via suppress ion of oxidative stress. With regard to the mechanism, we found that KAE down-regulated HDAC3 e xpression and up-regulated Nrf2 expression in ISO-induced rats and CoCl2-stimulated cardiomyocyte s. Incubation of cardiomyocytes with HDAC3-selective inhibitor RGFP966 augmented the protective eff ect of KAE and reduced oxidative stress. By contrast, HDAC3 overexpression by adenovirus attenuated the effect of KAE on oxidative stress compared with KAE treatment group. HDAC3 also regulated Nrf2 expre ssion in the cardiomyocytes with RGFP966 or an adenovirus overexpressing HDAC3; but Nrf2 inhib ition reduced the effect of KAE on ROS generation in CoCl2-induced⇑ Corresponding author. E-mail address: [email protected] (W. Wang). 1 These authors contributed equally to this article.
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38 reviews