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Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates by Xiao Yan, David Kuster, Priyesh Mohanty, Jik Nijssen, Karina Pombo-García, Jorge Garcia Morato, Azamat Rizuan, Titus M. Franzmann, Aleksandra Sergeeva, Anh M. Ly, Feilin Liu, Patricia M. Passos, Leah George, Szu-Huan Wang ISBN 10.1016/J.CELL.2025.04.039 instant download

  • SKU: EBN-238996640
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Instant download (eBook) Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates after payment.
Authors:Xiao Yan, David Kuster, Priyesh Mohanty, Jik Nijssen, Karina Pombo-García, Jorge Garcia Morato, Azamat Rizuan, Titus M. Franzmann, Aleksandra Sergeeva, Anh M. Ly, Feilin Liu, Patricia M. Passos, Leah George, Szu-Huan Wang
Pages:37 pages
Year:2025
Publisher:x
Language:english
File Size:24.78 MB
Format:pdf
ISBNS:10.1016/J.CELL.2025.04.039
Categories: Ebooks

Product desciption

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates by Xiao Yan, David Kuster, Priyesh Mohanty, Jik Nijssen, Karina Pombo-García, Jorge Garcia Morato, Azamat Rizuan, Titus M. Franzmann, Aleksandra Sergeeva, Anh M. Ly, Feilin Liu, Patricia M. Passos, Leah George, Szu-Huan Wang ISBN 10.1016/J.CELL.2025.04.039 instant download

Stress granules promote TDP-43 aggregation via intra-condensate demixing, a pathway triggered by its up-concentration and oxidation within condensates. Blocking this demixing pathway prevents TDP-43 aggregation, highlighting a potential therapeutic strategy for ALS/FTD diseases.
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