(Ebook) Inhaled Steroids in Asthma: Optimizing Effects in the Airways by Robert P. Schleimer ISBN 9780585416083, 9780824705855, 0824705858, 0585416087

(Ebook) Inhaled Steroids in Asthma: Optimizing Effects in the Airways by Robert P. Schleimer ISBN 9780585416083, 9780824705855, 0824705858, 0585416087

This book sums up the mechanistic basis, current status, and future prospects of steroid inhalation as the cornerstone of prophylactic asthma therapy, identifying its kinetic basis-especially the essential airway selectivity-and including a historical account of inhaled glucocorticoid development. Makes connections among the underlying pharmacology, impact of new simulation models, newly recognized molecular targets, and therapeutic outcomes of short- and long-term steroid inhalation therapy! Containing more than 1600 works cited, drawings, tables, equations, and micrographs, Inhaled Steroids in Asthma describes the developmental history of inhaled steroids and provides general models for lung selectivityconsiders the best way to select inhaled steroidsclarifies local metabolism, airway and lung uptake and retention, and other determinants of once-daily usageaddresses variations in lung deposition and total bioavailability among available steroids and formulationssurveys the dynamics of receptor gene-mediated processesanalyzes the role of chemokines in airway allergic inflammatory diseasesdiscusses the effects of inhaled steroids in vivo on cell progenitors in asthma and rhinitisdetails measuring airway inflammation as a guide for treatment decisionsoutlines the clinical relevancy of exhaled nitric oxide in asthmacovers optimal trial design for judging antiasthmatic potency and efficacyevaluates the safety of inhaled steroids Written by more than 40 of the world's leading authorities and investigators, Inhaled Steroids in Asthma is an authoritative reference for pulmonologists and pulmonary disease specialists; physiologists; allergists; immunologists; molecular, cell, and lung biologists; pediatricians; pharmaceutical scientists and pharmacologists; and medical school and upper-level undergraduate, graduate, and medical school students in these disciplines.