Hyperuricemia: A Renal Perspective - ECAB Clinical Updates: Nephrology by Jai Prakash ISBN 9788131231388, 9788131239438, 8131239438, 8131231380 instant download

Hyperuricemia: A Renal Perspective - ECAB Clinical Updates: Nephrology by Jai Prakash ISBN 9788131231388, 9788131239438, 8131239438, 8131231380 instant download

This book is an excellent compendium about a well known yet rediscovered topic, Hyperuricemia. Elevated serum uric acid levels has been a well accepted cause of gout and has been implicated in what was once called chronic gouty nephropathy, but recent developments have indicated its role in the development of renal disease, both acute and chronic, in addition to other systemic conditions like hypertension, cardiovascular disease, metabolic syndrome, pre-eclampsia, etc.
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Studies exploring the pathophysiological mechanisms indicate that reduction of the serum uric acid level may inhibit the cascade of events leading to the renal or vascular impairment, especially endothelial dysfunction. There is increasing evidence that uric acid is pathogenetically involved in essential hypertension; and lowering high uric acid in children with hyperuricemia and hypertension results in improvement of hypertension. Uric acid is also being implicated as an independent modifiable risk factor in cardiovascular disease and chronic renal disease; however, the evidence that reducing high uric acid levels reduces the incidence of both is lacking.
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Nevertheless, there is a ‘requirement for uric acid’ as well and I think the final word is yet to be written. This compendium fulfils this need to bring the current knowledge on this topic in various clinical conditions.