HSF-1 Regulates Autophagy to Govern Motor Function and Facilitate Toxic Protein Clearance in a C. elegans Model of Amyotrophic Lateral Sclerosis by Hui Xu & Yaping Shao & Jun Zhang & Yang Ni & Guowang Xu & Cong Liu & Yi Liang & Weidong Le instant download

HSF-1 Regulates Autophagy to Govern Motor Function and Facilitate Toxic Protein Clearance in a C. elegans Model of Amyotrophic Lateral Sclerosis by Hui Xu & Yaping Shao & Jun Zhang & Yang Ni & Guowang Xu & Cong Liu & Yi Liang & Weidong Le instant download

Neuroscience Bulletin,Abstract Heat shock factor-1 (HSF-1) plays a crucial role metabolic adaptation, providing new insights into the mechin orchestrating stress responses across diverse organisms anisms underlying ALS and potential targets for therapeutic and disease conditions. Here, we investigate how the HSF-1 intervention.signaling pathway infuences the degradation of toxic proteins and neuropathological changes in the Caenorhabditis Keywords ALS · Autophagy · Caenorhabditis elegans · elegans model of amyotrophic lateral sclerosis (ALS). We HSF-1 signaling pathway · Neuroprotectionfound that overexpressing HSF-1 improves locomotor ability and increases the survival rate of ALS C. elegans. Moreover, we observed a deceleration of motor neuron degeneraIntroductiontion, demonstrating the protective efect of HSF-1 on neurodegenerative processes. Transcriptomic analysis revealed Amyotrophic lateral sclerosis (ALS) stands as the most notable changes in genes associated with autophagy and prevalent degenerative motor neuron disorder globally neurodegeneration, underscoring HSF-1’s critical involve[1]. The most prevalent variant of this disease is linked to ment in ALS pathology. In addition, metabolomic proflmutations in copper-zinc superoxide dismutase 1 (SOD1) ing further highlighted the involvement of this pathway in [2, 3]. The pathogenic impact of SOD1 mutations is primetabolic reprogramming. Overall, our study underscores marily connected to the degeneration of motor neurons [4]. the critical role of the HSF-1 signaling pathway in improvDespite extensive research conducted over several decades, ing survival rate, movement velocity, cellular integrity, and the underlying mechanisms of ALS pathogenesis and the sp