Glycosylation in neuroinflammation: mechanisms, implications, and therapeutic strategies for neurodegenerative diseases by Shenglan Cheng & Bo Xiao & Zhaohui Luo instant download
Translational Neurodegeneration,AbstractNeuroinfammation is a key pathological mechanism underlying neurodegenerative diseases, and intricately interacts with protein glycosylation. Emerging evidence suggests that aberrant glycosylation disrupts immune homeostasis, activates microglia, and promotes the release of infammatory mediators, thereby exacerbating neuroinfammatory responses. In addition, the infammatory microenvironment can further dysregulate glycosylation patterns, creating a vicious cycle that amplifes disease pathology. Although the regulatory role of glycosylation in neuroinfammation associated with neurodegenerative diseases has been recognized, the precise molecular and cellular mechanisms remain incompletely understood. This review systematically examines the complex crosstalk between glycosylation and neuroinfammation, with a particular focus on the critical roles of glycosylation in key neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis. We explore how glycosylation abnormalities contribute to disease pathogenesis through efects on immune recognition, protein aggregation, and cellular functions. Understanding the molecular underpinnings of these diseases may pave the way for the development of therapeutic strategies targeting glycosylation pathways, ultimately improving clinical outcomes for patients.Keywords Neuroinfammation, Glycosylation, Neurodegenerative diseases, Microglia, IgG, Lectins, Targeted therapy
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