(Ebook) Genetics of Monogenic and Syndromic Obesity 1st Edition by Ya Xiong Tao ISBN 9780128046159 0128046155

Chapter One: Single Gene and Syndromic Causes of Obesity: Illustrative Examples

Abstract

1. Introduction and Background

2. Genetic Variant and Genome-Wide Association Studies in Obesity

3. Recognized Single Gene Causes of Obesity

4. Obesity Genes and Their Encoded Proteins

5. Syndromic Causes of Obesity

6. Prader–Willi Syndrome

7. Fragile X Syndrome and the Prader–Willi Phenotype

8. Alström Syndrome: A Rare Obesity-Related Single Gene Disorder

9. Albright Hereditary Osteodystrophy

Chapter Two: PCSK1 Variants and Human Obesity

Abstract

1. Introduction

2. Prohormone Convertase 1/3: General Properties

3. PC1/3 Substrates Involved in the Regulation of Energy Homeostasis and Food Behavior

4. PC1/3 Deficiency and Disease

5. Conclusions

Acknowledgments

Chapter Three: Rare Syndromes and Common Variants of the Brain-Derived Neurotrophic Factor Gene in Human Obesity

Abstract

1. Introduction

2. Human BDNF Haploinsufficiency

3. BDNF and Obesity in Other Disorders

4. Common Variants of BDNF

5. Conclusions

Acknowledgments

Chapter Four: Mutations in Melanocortin-3 Receptor Gene and Human Obesity

Abstract

Abbreviations

1. Obesity and Current Treatment

2. The Leptin-Regulated Melanocortin Circuit

3. Melanocortin-3 Receptor and Energy Homeostasis

4. Naturally Occurring Mutations in MC3R and Human Obesity

5. Potential Therapeutic Strategies

6. Conclusions

Acknowledgments

Chapter Five: Ghrelin Receptor Mutations and Human Obesity

Abstract

Abbreviations

1. Ghrelin System

2. Ghrelin System and Energy Homeostasis

3. Naturally Occurring GHSR Mutations

4. Summary

Chapter Six: Epigenetics of Obesity

Abstract

1. Introduction

2. How Epigenetic Changes are Related to Obesity

3. Epigenetics Studies in Human and Animals

4. Histone Modifications

5. miRNA

6. Epigenetic Effects of Maternal and Paternal Diet on Fetus Development

7. Transgenerational Effects

8. Obesogens

9. Epigenetic Changes in Response to Dietary Intervention

10. Concluding remarks

Chapter Seven: From Genome-Wide Association Study to Phenome-Wide Association Study: New Paradigms in Obesity Research

Abstract

Abbreviations

1. Introduction

2. Current Clinical Classification of Obesity

3. Genetics, Heritability, and Genome-Wide Association Study of Obesity

4. Lifestyle and Environmental Impacts and Epigenetics of Obesity

5. Phenome-Wide Association Study of Obesity

6. Summary

Acknowledgments

Chapter Eight: Genetics of Adiposity in Large Animal Models for Human Obesity—Studies on Pigs and Dogs

Abstract

1. Introduction

2. Breed Specific Differences of Adipose Tissue Accumulation

3. Epigenetic Markers of Adipogenesis and Adipose Tissue

4. QTL for Adiposity Traits

5. Polymorphisms Associated With Fat Tissue Accumulation

6. Conclusions and Perspectives

Acknowledgments

Index